Particulate Matter

This report describes the results of a study of long-term effects of PM components in the American Cancer Society's Cancer Prevention Study II cohort; a time-series study of short-term effects of PM components on cardiovascular and other diseases in people living in 150 U.S. cities; and two toxicologic studies in animals exposed by inhalation to concentrated ambient particles, and in animals and human cells exposed to particles collected on filters from five different airsheds across the United States. This report, along with Research Report 178 (Vedal et al.), is one of HEI's National Particle Component Toxicity (NPACT) studies, which describe the most systematic multidisciplinary studies to date to investigate the health effects of PM components in humans and animal models at locations across the United States where the effects of PM sources and components may differ. The report includes a Commentary and a Synthesis by the NPACT Review Panel.

This report describes a study to evaluate a series of aggressive policies intended to reduce local and regional emissions in the greater Beijing metropolitan area leading up to and during the 2008 Olympics. Dr. Junfeng (Jim) Zhang of the University of Medicine and Dentistry of New Jersey and colleagues evaluated the impact of the likely changes in air pollution levels on cardiovascular responses in 125 healthy young participants before, during, and after the Beijing Olympics. The investigators used mixed models and time-series methods to analyze associations between pollutant levels and biomarkers.

Contents: Review of Ultrafine Particles Examines Wide Range of Health Studies; Timely Topics, Great City Highlight HEI Annual Conference; Tool Helps Identify Nanoparticles from Motor Vehicles; Air Pollution Controls During 2008 Beijing Olympics; Science Workshop to Inform European Union Policies; Study Finds Ambient Air Pollution Among Top Global Health Risks; ACES Emissions Testing and Animal Exposures Now Complete

This report describes a study that analyzed the relationships between reductions in pollutants from power plants and fine particulate matter (PM_2.5) concentrations in the eastern United States between 1999 and 2005. Dr. Richard D. Morgenstern of Resources for the Future and colleagues used a novel data-driven source-receptor model to explore the statistical relationships between source emissions of sulfur dioxide (SO₂) and nitrogen oxides and monitored concentrations of PM_2.5. They performed various external comparisons of their models, and compared the reductions to an estimated counterfactual scenario in which no mandated reductions in SO₂ occurred.