National Particle Component Toxicity (NPACT) Initiative: Integrated Epidemiologic and Toxicologic Studies of the Health Effects of Particulate Matter Components

NPACT Study 1. Subchronic Inhalation Exposure of Mice to Concentrated Ambient PM_2.5 from Five Airsheds Lung-Chi Chen and Morton Lippmann

NPACT Study 2. In Vitro and in Vivo Toxicity of Exposure to Coarse, Fine, and Ultrafine PM from Five Airsheds Terry Gordon, Morton Lippmann, Arthur Nádas, and Christina Hickey

NPACT Study 3. Time-Series Analysis of Mortality, Hospitalizations, and Ambient PM_2.5 and Its Components Kazuhiko Ito, Zev Ross, Jiang Zhou, Arthur Nádas, Morton Lippmann, and George D. Thurston

NPACT Study 4. Mortality and Long-Term Exposure to PM_2.5 and Its Components in the American Cancer Society's Cancer Prevention Study II Cohort George D. Thurston, Kazuhiko Ito, Ramona Lall, Richard T. Burnett, Michelle C. Turner, Daniel Krewski, Yuanli Shi, Michael Jerrett, Susan M. Gapstur, W. Ryan Diver, and C. Arden Pope III

This report describes the results of a study of long-term effects of PM components in the American Cancer Society's Cancer Prevention Study II cohort; a time-series study of short-term effects of PM components on cardiovascular and other diseases in people living in 150 U.S. cities; and two toxicologic studies in animals exposed by inhalation to concentrated ambient particles, and in animals and human cells exposed to particles collected on filters from five different airsheds across the United States. This report, along with Research Report 178 (Vedal et al.), is one of HEI's National Particle Component Toxicity (NPACT) studies, which describe the most systematic multidisciplinary studies to date to investigate the health effects of PM components in humans and animal models at locations across the United States where the effects of PM sources and components may differ. The report includes a Commentary and a Synthesis by the NPACT Review Panel.