Biological Methods

This page has a list of publications and news articles related to Innovative Strategies - Biological Methods. Find more information on Innovation in HEI's research programs.

Study evaluates mechanisms of lung injury by ozone

March 30, 2021

HEI has published Research Report 204, Novel Mechanisms of Ozone-Induced Pulmonary Inflammation and Resolution, and the Potential Protective Role of Scavenger Receptor BI, presenting a study led by Dr. Kymberly Gowdy of East Carolina University (now at Ohio State University).

Research Report 204
Kymberly Gowdy
Brita Kilburg-Basnyat
Myles X Hodge
Sky W Reece
Valery Yermalitsky
Sean S Davies
Jonathan Manke
Michael L Armstrong
Nichole Reisdorph
Robert M Tighe
S Raza Shaikh
March 2021

Research Report 204 presents a study led by Dr. Kymberly Gowdy of East Carolina University (now at Ohio State University) and colleagues in which they evaluated how acute exposure of mice to ozone affects initiation and resolution of the inflammatory response in the lung.

Summer 2020 Update now available

August 17, 2020

In the new issue of Update, read about two new HEI Board members; HEI’s formal response to EPA’s proposed transparency rule; a new chair for our Review Committee; HEI’s actions to promote diversity; a recently published Walter A. Rosenblith New Investigator report on novel techniques to study VOC–ozone effects… and more!

Newsletter
Health Effects Institute
August 2020

In this issue of Update, read about two new HEI Board members; HEI’s formal response to EPA’s proposed transparency rule; a new chair for our Review Committee; HEI’s actions to promote diversity; a recently published Walter A. Rosenblith New Investigator report on novel techniques to study VOC–ozone effects… and more!

New HEI report examines pollutant effects on lung cells

July 28, 2020

HEI has published Research Report 201, Understanding the Functional Impact of VOC–Ozone Mixtures on the Chemistry of RNA in Epithelial Lung Cells, led by Dr. Lydia Contreras at the University of Texas, Austin.

Research Report 201
Lydia M Contreras
Juan C Gonzalez-Rivera
Kevin C Baldridge
Dongyu S Wang
Jamie CL Chuvalo-Abraham
Lea Hildebrandt Ruiz
July 2020

Research Report 201 presents a study led by Dr. Lydia Contreras at the University of Texas, Austin, who is a recipient of HEI’s Walter A. Rosenblith New Investigator Award. Dr. Contreras and colleagues evaluated how exposure of lung cells to volatile organic compounds plus ozone affects oxidation of ribonucleic acid, a key component of cells. The study aimed to improve understanding of the biological mechanisms by which air pollutants can cause effects in human health, thereby expanding our knowledge of potential causal links between exposure and health.

Two new Rosenblith Awardees selected for 2019

December 17, 2019

HEI is pleased to announce that the recipients of the 2019 Walter A. Rosenblith New Investigator Award are Tanya Alderete, assistant professor of epidemiology at the University of Colorado, and Megan Herting, assistant professor of epidemiology at the University of Southern California in Los Angeles (USC).

Walter A. Rosenblith New Investigator Award announced

October 31, 2018

Manabu Shiraiwa, who was recently promoted to associate professor in the Department of Chemistry at the University of California, Irvine, was selected to receive HEI’s 2018 Walter A. Rosenblith New Investigator Award for his proposal “Formation of Reactive Oxygen Species by Organic Aerosols and Transition Metals in Epithelial Lining Fluid.”

Unpublished Report
William E Kraus
Elizabeth R Hauser
Susanne Breitner
Alexandra Schneider
Akihiko Nishimura
Damian M Craig
Svati H Shah
October 2018

This unpublished report describes a three-year study aimed at examining the effects of short-term and long-term air pollution exposure on cardiovascular disease outcomes in a high-risk population, linking biomarker and genomic data to air quality data. Kraus and colleagues at Duke University used previously collected data from CATHGEN, a cohort of approximately 7,000 individuals undergoing coronary artery catheterization in North Carolina between 2001 and 2010.

This newsletter reports on the approval of new HEI studies to examine potential health effects of low-level pollution; the completion of a review of diesel exhaust studies (Special Report 19) by an HEI-appointed panel; and WHO's plans to update global air quality guidelines. In addition, it announces the publication of an HEI report taking a closer look at exposure to PM2.5 and its composition and a report evaluating rapid heart rhythm changes after exposure to PM. HEI also announces the recipient of the 2015 Walter A. Rosenblith New Investigator Award and the appointment of three new HEI Research Committee members.