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Ongoing Research
At any given time, HEI has a variety of ongoing studies at various stages of completion. Here, you will find a list of studies with more detailed information for each, including abstracts and posters presented at HEI Annual Conferences. We also indicate which studies have been completed and are currently undergoing HEI’s rigorous review process.
Ongoing Studies
Accountability Studies
Studies funded under RFA 23-2, Assessing Changes in Exposures and Health Outcomes in Historically Marginalized and Environmentally Overburdened Communities from Air Quality Actions, Programs, or Other Interventions; RFA 18-1, Assessing Improved Air Quality and Health From National, Regional, and Local Air Quality Actions; and HEI’s Open and Rosenblith RFAs
Accountability Studies
Studies funded under RFA 23-2, Assessing Changes in Exposures and Health Outcomes in Historically Marginalized and Environmentally Overburdened Communities from Air Quality Actions, Programs, or Other Interventions; RFA 18-1, Assessing Improved Air Quality and Health From National, Regional, and Local Air Quality Actions; and HEI’s Open and Rosenblith RFAs
In this HEI-funded project, the investigators will build on their previous accountability analyses in Atlanta, New York, and Los Angeles to characterize the health impacts of MV and EGU policy implementation.
What? Identify the health and equity impacts of state and local zoning policies for minimizing traffic-related air pollution (TRAP) from commercial vehicle fleets and distribution centers serving residential delivery in the Seattle and New York City areas.
How? Develop scenarios and analyze the health effects and equity implications of future low- and zero-emission vehicle procurement programs, truck delivery efficiency improvements, and urban land use policies on logistics-related development. The project integrates stakeholder interviews, policy scans, traffic demand modeling, and simulation to estimate the health risks of chronic exposure to e-commerce-related TRAP in marginalized communities.
Where? Seattle and New York City.
This study will focus on a coal ban and heat pump subsidy program in the Beijing, China, region. They are building on an existing panel study that is following about 966 people who live in 50 villages around Beijing. Half the villages are subject to the policy, the other half are not.
What? Examine the air quality, health, and equity implications of adoption of US EPA Clean truck rule, Advanced Clean Trucks regulation, and vehicle omnibus regulation in Chicago and whether policy-driven air pollution changes in Chicago are transferable nationwide.
How? 1. Use new satellite data, along with other publicly available datasets, to improve the accuracy of nationwide heavy-duty vehicle emissions, with a focus on emissions from warehouse environments. 2. Use updated emissions estimates in a high-resolution chemical transport model to understand how warehousing-related emissions and emission reduction policies affect exposures, health, and equity.
Where: Chicago and Nationwide.
This study will assess the effects of emission-control measures on birth outcomes associated with traffic-related air pollution in Texas. Hystad and colleagues will evaluate air quality changes associated with national motor vehicle emissions regulations, as well as a diverse array of local congestion reduction programs implemented in Texas over the past 25 years.
This study will evaluate the major national regulatory policies that were implemented in China from 2008–2018. The investigators will focus on regulations in particular regions that target specific sources, such as coal combustion, and how they have reduced ambient concentrations of fine particles (and their components).
What? Assess the effects of California’s Advanced Clean Trucks and Advanced Clean Fleets regulations on air pollutant exposure and health disparities in Southern California.
How? Estimate the impact of recently adopted zero-emission truck regulations changes on tailpipe and non-tailpipe pollutant emissions, refine an air quality model to simulate the corresponding changes in air pollutant concentrations, and assess disparities in exposures and health outcomes (mortality and asthma emergency department visits) in freight transport communities in Southern California.
Where: Southern California.
COVID-19, Air Pollution, and Health Studies
HEI funded five different COVID-19 studies under RFA 20-1B. Two of these studies have been published; see Research Report 214 (Andersen et al.) and Research Report 220 (Tonne et al.). Studies in progress or under review are listed below. This research is taking place in the United States, Europe, and Asia and it focuses on two key areas:
- Accountability studies: Evaluating how interventions to control the pandemic might have affected emissions, air pollution, and human health.
- Susceptibility studies: Evaluating how air pollution exposure might affect the COVID-19 disease course, and how race, ethnicity, and socioeconomic status might also play a role.
COVID-19, Air Pollution, and Health Studies
HEI funded five different COVID-19 studies under RFA 20-1B. Two of these studies have been published; see Research Report 214 (Andersen et al.) and Research Report 220 (Tonne et al.). Studies in progress or under review are listed below. This research is taking place in the United States, Europe, and Asia and it focuses on two key areas:
- Accountability studies: Evaluating how interventions to control the pandemic might have affected emissions, air pollution, and human health.
- Susceptibility studies: Evaluating how air pollution exposure might affect the COVID-19 disease course, and how race, ethnicity, and socioeconomic status might also play a role.
This multicountry study will evaluate whether changes in mortality are associated with changes in ambient NO2 and PM2.5 levels before, during, and after the lockdown and disentangle the short-term effects of NO2 versus PM2.5 on mortality. The analysis will be conducted in four countries: China, Germany, Italy, and the United States.
This study will investigate the chronic and acute effects of air pollution exposure on COVID-19 incidence, mortality, and long-term complications, including onset of disease formation. Long- (2017−2018) and short- (2020) term exposures will be linked to a large medical records database in Southern California, with assessments at both the neighborhood and individual level.
In this study the investigators will conduct a retrospective evaluation of the interactions between long-term exposure to air pollution and neighborhood vulnerability to adverse COVID-19 outcomes. They will investigate both single and multipollutant air pollution exposures in relation to COVID-19 hospitalization, inpatient length of stay, ICU admission, ventilator use, and death among a racially diverse population in New York City.
Enhanced Exposure Studies
Enhanced Exposure Studies
This study aims to improve our understanding of the contribution of individual mobility in air pollution exposure estimates. The investigators will use location tracking on a mobile phone application for 2,000 individuals in the Netherlands and Switzerland.
Hoek and colleagues will prepare maps of modeled annual average air pollution across the Netherlands, validate the maps using new measurements from over 100 sites, and evaluate the performance of several exposure models. The investigators will conduct cross-comparisons to evaluate how different exposure assessment methods compare in their ability to predict long-term pollutant concentrations, with a particular focus on spatial variability of pollutants.
This study will investigate the consequences of measurement error on estimates of health effects of long-term exposure to outdoor air pollution in London by developing increasingly sophisticated exposure models.The investigators plan to compare exposure models that account for mobility, are based on exposure estimates at the residential address, and are based on concentrations measured at the nearest air pollution monitor.
This study will compare and contrast scientific and logistical benefits of different approaches to air pollution exposure assessment. The investigators will leverage large air pollution datasets obtained from low-cost sensors, mobile monitoring, and passive samplers. They will apply the exposure assessment approaches to determine associations with cognitive decline and dementia incidence in an ongoing cohort study, Adult Changes in Thought Air Pollution (ACT-AP).
Quantifying Real-World Impacts of Non-Tailpipe Particulate Matter Emissions
Quantifying Real-World Impacts of Non-Tailpipe Particulate Matter Emissions
This study will measure concentrations of non-tailpipe particulate matter across Toronto, Canada, to determine how much non-tailpipe pollution people might breathe in everyday life and how to better measure these exposures in the future.
In this study, participants with mild to moderate asthma will ride stationary bicycles on sidewalks in three London, UK environments (busy road characterized by stop-and-go traffic, high speed continuous traffic, and urban background) to measure how exposure to traffic with different mixtures of non-tailpipe and tailpipe emissions affects lung function of asthmatic adults.
Traffic Exposure and Health Studies
Studies funded under RFQ 24-1, Benefits Assessment of Accelerated Turnover of the On-Road Diesel Vehicle Fleet in the United States; RFA 23-1, Assessing Health Effects of Traffic-Related Air Pollution in a Changing Urban Transportation Landscape; and RFA 17-1, Assessing Adverse Health Effects of Exposure to Traffic-Related Air Pollution, Noise, and Their Interactions With Socio-Economic Status.
Traffic Exposure and Health Studies
Studies funded under RFQ 24-1, Benefits Assessment of Accelerated Turnover of the On-Road Diesel Vehicle Fleet in the United States; RFA 23-1, Assessing Health Effects of Traffic-Related Air Pollution in a Changing Urban Transportation Landscape; and RFA 17-1, Assessing Adverse Health Effects of Exposure to Traffic-Related Air Pollution, Noise, and Their Interactions With Socio-Economic Status.
This project will link and extend several models to create a framework for full-chain assessment of transportation systems and impacts of traffic-related air pollution (TRAP) on population health in the San Francisco Bay Area. The investigators will evaluate impacts of three policy scenarios — federal/California long-term transportation electrification, telecommuting impact from COVID-19, and a community-led scenario — on exposure to TRAP and associated mortality and morbidity outcomes, including environmental justice disparities.
In this study, the investigators will recruit pregnant women in Barcelona and assess the effects of in-utero exposure to traffic-related pollution on birth weight, fetal growth trajectories, and placental function for each pregnancy. The investigators will estimate exposure to several pollutants and transportation noise and evaluate the roles of socioeconomic status, green space, physical activity, diet, and stress.
This study will assess the effects of metals from nontailpipe emissions on asthma and lung function in the most recent cohort of the Children’s Health Study in Southern California (recruited during 2002-2012), using available filters with particulate matter samples. The investigators will estimate exposure to several pollutants and transportation noise and evaluate the roles of socioeconomic status, green space, physical activity, diet, and stress.
This project will leverage an existing randomized control trial of older individuals in the United States to examine the associations of exposure to traffic-related air pollution and incident cardiovascular disease events and biomarkers of cardiovascular health. The investigators will also explore the potential for vitamin D and omega-fatty acid supplementation to modify the associations.
Horton and colleagues will assess changes in air quality in an area of the west side of Chicago, Illinois, that they have confirmed is heavily affected by diesel emissions based on air pollution measurements, numerical air quality modeling, lived experience, high-density diesel activity around warehousing and intermodal facilities, high truck traffic counts, and disadvantaged and underinvested communities. They will conduct a census-tract–level health impact assessment and equity-focused analysis using associations from the literature. Scenarios to be compared are (1) current air pollution exposure and health impacts associated with older medium- and heavy-duty vehicle tailpipe emissions and (2) setting tailpipe emissions from pre-2010 medium- and heavy-duty vehicles to lower levels in line with newer vehicle fleet emissions. Analyses will incorporate community input, air quality modeling, and a health equity analysis to inform policy decisions.
This project will assess the impacts of future urban transportation landscapes on cardiometabolic health through novel exposure estimation together with air quality modeling of traffic-related air pollution (TRAP). Exposures will be associated with markers of cardiovascular diseases using an existing population-based cohort in Augsburg, Germany. Findings will be then scaled up to the whole study area population (Munich metropolitan area), and eventually all of Germany. Various transportation scenarios will be evaluated, such as those related to transport infrastructure, technological advancements, and pricing policies.
This project will develop models relevant for characterizing exposures from vehicle (tailpipe and non-tailpipe), rail, and aircraft sources and relate those exposures to birth outcome data in the Los Angeles area. They will also include a social vulnerability analysis and will assess the effect of electric vehicles, flight technologies, and the COVID-19 travel disruptions on air pollution and birth outcomes.
This study will assess myocardial infarction, stroke, diabetes, and biomarkers related to cardiovascular disease and diabetes in three large Danish cohorts. The investigators will estimate exposure to several pollutants and transportation noise and evaluate the roles of socioeconomic status, green space, physical activity, diet, and stress.
Wildland Fires and Agricultural Burning Studies
Wildland Fires and Agricultural Burning Studies
This study is investigating risk of birth outcomes and perinatal mortality from fire-related PM2.5. The interdisciplinary team is developing fire modeling methods to estimate PM2.5 specifically from fires for Australia with improved fire emissions inventories and Lagrangian modeling.
The objectives of this study are to: 1) Estimate the contributions of prescribed burning to both fine particulate matter (PM2.5) and ozone (O3) levels in the Southeastern US; 2) Quantify the effects of prescribed fire smoke on rates of emergency department (ED) visits; and 3) Assess how the observed health impacts vary across strata defined by age, sex, and socioeconomic markers.
Walter A. Rosenblith Award
This New Investigator Award study will investigate whether prenatal and/or early-life exposure to air pollutants affects the infant gut microbiota and fecal metabolome, thereby altering infant growth trajectories in the first two years of life. Dr. Alderete plans to study this in an ongoing longitudinal cohort of Hispanic mother-infant pairs in California with existing validated clinical assessments of infant growth trajectories. She will also use gut microbial profiling and high-resolution fecal metabolomics profiles to understand the mechanisms underlying the obesogenic effects of air pollutants in early life.
This New Investigator Award study seeks to develop statistical methodology that allows for complex relationships between air pollution and health outcomes to be used to estimate causal effects of multivariate exposures. Additionally, the proposed methodology will allow for evaluation of separate subgroups in the population to identify the most vulnerable subgroups.
This New Investigator Award study seeks to examine associations of long-term maternal exposures to PM2.5, NO2, and environmental noise with adverse birth outcomes in Accra, Ghana. The investigators also seek to determine the effect of these exposures on the risk of lower respiratory infections in infants.
The primary objective of this study, led by HEI's 2021 Walter A. Rosenblith New Investigator Award recipient Lucas Henneman, is to create fine-scale daily PM2.5 source impacts from major source and fuel categories from 2011-2020. This objective builds on recent work developing fine-scale daily air pollution exposure products in the United States, which have driven recent epidemiological studies on air pollution health effects.
This New Investigator Award study is evaluating how fine-particle exposure affects the development of prefrontal connections and emotional behaviors during the transition from childhood to adolescence and whether this, in turn, contributes to greater risk for neuropsychiatric disorders.
Dr. Nethery’s study seeks to develop statistical methods for characterizing spatial and racial and ethnic variation in health effects associated with exposure to fine particulate matter (PM2.5) across the United States, and to design potential policies for reducing PM2.5-attributable health inequities.
Dr. Ornelas Van Horne’s study seeks to advance a community-academic partnership with Missouri Breaks Industries Research (an American Indian-owned research center serving Indigenous communities and others in North and South Dakota) and Columbia University to characterize sources of air pollution and identify community-driven solutions through an emissions reduction plan.
