Research Reports

HEI’s mission is to provide credible science to support environmental regulations and other policy decisions. The results of each HEI-funded project undergo peer-review by outside scientists and the Health Review Committee. The HEI Research Reports contain the Investigator’s Report and the Review Committee’s evaluation of the study, summarized in a Commentary or short Critique.

ISSN 1041-5505 (print)        ISSN 2688-6855 (online) 

Research Report 208
Bert Brunekreef
Maciej Strak
Jie Chen
Zorana J Andersen
Richard Atkinson
Mariska Bauwelinck
et al.
2021

Research Report 208 presents a study by Bert Brunekreef at the Institute for Risk Assessment Sciences, Utrecht University, the Netherlands, and colleagues examining associations between exposures to relatively low levels of air pollution below the current EU standards and several health outcomes among participants in 22 European cohorts. 
 

Research Report 206
Jane E Clougherty
Jamie L Humphrey
Ellen J Kinnee
Lucy F Robinson
Leslie A McClure
Laura D Kubzansky
Colleen E Reid
2021

Research Report 206 presents a study led by Dr. Jane Clougherty at Dornsife School of Public Health, Drexel University. Clougherty and colleagues examined whether associations between community- and individual-level cardiovascular disease events and ambient air pollutants vary by social stressors.  

Research Report 205
Ying-Ying Meng
Jason G Su
Xiao Chen
John Molitor
Dahai Yue
Michael Jerrett
2021

Research Report 205 presents a study led by Ying-Ying Meng and colleagues at the University of California, Los Angeles, examining the impact of the 2006 California Goods Movement Plan on air quality and healthcare utilization among adults with chronic health conditions who were enrolled in California’s healthcare program for low-income individuals (Medi-Cal).

Research Report 204
Kymberly Gowdy
Brita Kilburg-Basnyat
Myles X Hodge
Sky W Reece
Valery Yermalitsky
Sean S Davies
Jonathan Manke
Michael L Armstrong
Nichole Reisdorph
Robert M Tighe
S Raza Shaikh
2021

Research Report 204 presents a study led by Dr. Kymberly Gowdy of East Carolina University (now at Ohio State University) and colleagues in which they evaluated how acute exposure of mice to ozone affects initiation and resolution of the inflammatory response in the lung.

Research Report 201
Lydia M Contreras
Juan C Gonzalez-Rivera
Kevin C Baldridge
Dongyu S Wang
Jamie CL Chuvalo-Abraham
Lea Hildebrandt Ruiz
2020

Research Report 201 presents a study led by Dr. Lydia Contreras at the University of Texas, Austin, who is a recipient of HEI’s Walter A. Rosenblith New Investigator Award. Dr. Contreras and colleagues evaluated how exposure of lung cells to volatile organic compounds plus ozone affects oxidation of ribonucleic acid, a key component of cells. The study aimed to improve understanding of the biological mechanisms by which air pollutants can cause effects in human health, thereby expanding our knowledge of potential causal links between exposure and health.

Research Report 192, Part 2
David Q Rich
Mark W Frampton
John R Balmes
Philip A Bromberg
Mehrdad Arjomandi
Milan J Hazucha
Sally W Thurston
Neil E Alexis
Peter Ganz
Wojciech Zareba
Petros Koutrakis
Kelly Thevenet-Morrison
2020

Research Report 192, Part 2, describes the second part of the Multicenter Ozone Study in oldEr Subjects (MOSES), led by Drs. David Rich and Mark Frampton of the University of Rochester Medical Center in Rochester, New York. Part 1 of the MOSES study, Effects of Exposure to Low Concentrations of Ozone on Respiratory and Cardiovascular Outcomes, was published in 2017; Part 2 presents additional analyses.

Research Report 202
Stuart Batterman
Veronica J Berrocal
Chad Milando
Owais Gilani
Saravanan Arunachalam
K Max Zhang
2020

Research Report 202 describes a study led by Dr. Stuart Batterman at the University of Michigan, Ann Arbor and colleagues. The investigators evaluated the ability to predict traffic-related air pollution using a variety of methods and models, including a line source air pollution dispersion model and sophisticated spatiotemporal Bayesian data fusion methods.

Research Report 203
Michael Brauer
Jeffrey R Brook
Tanya Christidis
Yen Chu
Dan Crouse
Anders Erickson
Perry Hystad
Chi Li
Randall V Martin
Jun Meng
Amanda J. Pappin
Lauren L. Pinault
Michael Tjepkema
Aaron van Donkelaar
Scott Weichenthal
Richard T Burnett
2019

Research Report 203 describes the first-phase results of a study evaluating the relationship between long-term exposure to low concentrations of PM2.5 and non-accidental mortality, including a characterization of the shape of the concentration–response functions, in a large population-based cohort (~9 million adults) in Canada. The report also presents the detailed Commentary on the study by HEI’s Low-Exposure Epidemiology Studies Review Panel.

Research Report 200
Francesca Dominici
Joel Schwartz
Qian Di
Danielle Braun
Christine Choirat
Antonella Zanobetti
2019

Research Report 200 describes the first-phase results of a study examining any association between exposure to low levels of air pollution — both PM2.5 and O3 — and all-cause mortality in a population of 61 million Medicare enrollees residing in the continental United States. The report also presents the detailed Commentary on the study by HEI’s Low-Exposure Epidemiology Studies Review Panel.

Research Report 198
Jason D Surratt
Ying-Hsuan Lin
Maiko Arashiro
William G Vizuete
Zhenfa Zhang
Avram Gold
Ilona Jaspers
Rebecca C Fry
2019

Research Report 198 describes a study by Dr. Jason Surratt and his colleagues evaluating the toxicity of fine particulate matter formed from the photochemical oxidation of isoprene in a chamber.