Ozone (O3) is a reactive gas that has been associated with adverse health effects in children and adults. Effects on the respiratory system are well established and include exacerbation of asthma (acute effects) and effects on lung growth (chronic effects). More recently, long-term exposure to ozone has been associated with adverse cardiovascular outcomes, including increased mortality. It is unclear, however, at what ozone concentrations effects start occurring. HEI's research program on ozone focuses on effects at low concentrations and on mechanisms of effects.
Ozone in a nutshell:
Ozone is created by atmospheric reactions on sunny days
Building blocks are nitrogen oxides and volatile organic compounds
Ground level ozone affects lung and heart health and affects crops
This New Investigator Award study is evaluating whether injury after exposure to ozone is mediated through changes in the lung and blood of levels of oxidized phospholipids. This will be tested in normal mice and in mice genetically lacking the Scavenger Receptor B1 that binds oxidized phospholipids.