Ozone (O3) is a reactive gas that has been associated with adverse health effects in children and adults. Effects on the respiratory system are well established and include exacerbation of asthma (acute effects) and effects on lung growth (chronic effects). More recently, long-term exposure to ozone has been associated with adverse cardiovascular outcomes, including increased mortality. It is unclear, however, at what ozone concentrations effects start occurring. HEI's research program on ozone focuses on effects at low concentrations and on mechanisms of effects.
Ozone in a nutshell:
Ozone is created by atmospheric reactions on sunny days
Building blocks are nitrogen oxides and volatile organic compounds
Ground level ozone affects lung and heart health and affects crops
This New Investigator Award study is evaluating whether injury after exposure to ozone is mediated through changes in the lung and blood of levels of oxidized phospholipids. This will be tested in normal mice and in mice genetically lacking the Scavenger Receptor B1 that binds oxidized phospholipids.
This study evaluated the hypothesis that bronchial airway reactivity in response to ozone exposure is modulated by the bone marrow production of certain eosinophils that have a beneficial effect upon airway function. This study evaluated guinea pigs exposed to 0.1 and 0.2 ppm of ozone.
This statistical data analysis center developed an analysis plan, managed data, and analyzed data collected in the multicenter controlled ozone exposure study in human volunteers. For more information see RFA 10-1 and the study by Drs.John Balmes, Philip Bromberg, and Mark Frampton.
This multi-center study focused on the effects of ozone in human volunteers, aged 55 to 70 years, who were exposed in chambers to near ambient levels of ozone with intermittent exercise. Effects on the cardiovascular system, along with changes in pulmonary function, inflammation and oxidative stress were studied.