Biological Methods

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This page has a list of publications and news articles related to Innovative Strategies - Biological Methods. Find more information on Innovation in HEI's research programs.

The Effects of Exercise on Dose and Dose Distribution of Inhaled Automotive Pollutants

Research Report 45

Michael T Kleinman

William J Mautz

1991

Topics:

The human health effects that result from breathing air pollutants depend on the amount of pollutant inhaled from the air (exposure dose) and the amount of inhaled material that stays in the respiratory tract (retained dose). Because the retained dose of a pollutant may damage the respiratory tract and cause disease, it is a key factor for determining appropriate government regulations for air pollutants. Drs.

Retention Modeling of Diesel Exhaust Particles in Rats and Humans

Research Report 40

CP Yu

KJ Yoon

1991

Topics:

Diesel Exhaust

Biological Methods

This report describes a study by Drs. Yu and Yoon to mathematically predict the lung burden in rats and humans of diesel exhaust particles (DEP) from automobile emissions. Building on a previously constructed model describing DEP deposition, the present work focused on clearance and retention of DEPs deposited in the lung. The transport rates of each component of DEPs were derived using experimental data and mathematical approximations. The complete model was first developed for rats and then extrapolated to humans of different age groups.

Noninvasive Determination of Respiratory Ozone Absorption: Development of a Fast-Responding Ozone Analyzer

Research Report 39

James S Ultman

Abdellaziz Ben-Jebria

1991

Topics:

Ozone & Oxidants

Biological Methods

This report describes a study by Drs. Ultman and Ben-Jebria to develop a chemiluminescent ozone analyzer and constructed an ozone bolus generator with the goal of using bolus concentration-response methods to noninvasively measure the longitudinal distribution of ozone absorption in human lungs. The analyzer was based on the chemiluminescent reaction between 2-methyl-2-butene and ozone. Validation of the system was performed in excised pig and sheep tracheas, and the resulting absorption coefficient was computed.

Predictive Models for Disposition of Inhaled Diesel Exhaust Particles in Humans and Laboratory Species

Research Report 10

CP Yu

GB Xu

1987

Topics:

Diesel Exhaust

Biological Methods

Dr. Yu's project addressed several important issues regarding improved quantification of dose from known concentrations of atmospheric particulate matter. By focusing first on a specific category of automotive-derived particles, diesel exhaust particulate, Dr. Yu was able to characterize those aerosol properties (such as the mass medican aerodynamic diameter and size distribution) that influence regional deposition. After formulating a mathematical deposition model, Dr.

HEI releases report on how lungs react to pollutants

December 5, 2023

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Study evaluates mechanisms of lung injury by ozone

March 30, 2021

HEI has published Research Report 204, Novel Mechanisms of Ozone-Induced Pulmonary Inflammation and Resolution, and the Potential Protective Role of Scavenger Receptor BI, presenting a study led by Dr. Kymberly Gowdy of East Carolina University (now at Ohio State University).

Summer 2020 Update now available

August 17, 2020

In the new issue of Update, read about two new HEI Board members; HEI’s formal response to EPA’s proposed transparency rule; a new chair for our Review Committee; HEI’s actions to promote diversity; a recently published Walter A. Rosenblith New Investigator report on novel techniques to study VOC–ozone effects… and more!

New HEI report examines pollutant effects on lung cells

July 28, 2020

HEI has published Research Report 201, Understanding the Functional Impact of VOC–Ozone Mixtures on the Chemistry of RNA in Epithelial Lung Cells, led by Dr. Lydia Contreras at the University of Texas, Austin.

Two new Rosenblith Awardees selected for 2019

December 17, 2019

HEI is pleased to announce that the recipients of the 2019 Walter A. Rosenblith New Investigator Award are Tanya Alderete, assistant professor of epidemiology at the University of Colorado, and Megan Herting, assistant professor of epidemiology at the University of Southern California in Los Angeles (USC).

Walter A. Rosenblith New Investigator Award announced

October 31, 2018

Manabu Shiraiwa, who was recently promoted to associate professor in the Department of Chemistry at the University of California, Irvine, was selected to receive HEI’s 2018 Walter A. Rosenblith New Investigator Award for his proposal “Formation of Reactive Oxygen Species by Organic Aerosols and Transition Metals in Epithelial Lining Fluid.”