This page is a list of publications in reverse chronological order. Please use search or the filters to browse by research areas, publication types, and content types.

Displaying 221 - 230 of 292. Show 10 | 25 | 50 | 100 results per page.

Consequences of Prolonged Inhalation of Ozone on F344/N Rats: Collaborative Studies. Part I: Content and Cross-Linking of Lung Collagen

Jerold A Last
Thomas R Gelzleichter
Jack R Harkema
Susan Hawk
April 1994
Research Report 65-I

Ozone is a highly reactive gas that is a pervasive air pollutant at ground level. It is a major component of urban smog, forming when emissions from mobile and industrial sources interact with sunlight. The study of the effects of long-term ozone exposure on lung collagen, described in this report, was one of eight studies in a Collaborative Project supported by the NTP and the HEI. The others included studies of lung biochemistry, structure, and function, and one study of nasal structure and function. Dr.

Environmental Epidemiology Planning Project

Health Effects Institute
March 1994
Communication 3

HEI conducted the Environmental Epidemiology Planning Project in order to identify research needs and opportunities in selected areas of environmental epidemiology. Working groups in each selected area prepared documents composed of individually authored papers. The Planning Project documents were originally published in Environmental Health Perspectives (December 1993, Vol. 102).

Development of Samplers for Measuring Human Exposure to Ozone

Jack D Hackney
Petros Koutrakis
Yukio Yanagisawa
February 1994
Research Report 63

Ozone is a highly reactive gas that is a pervasive air pollutant at ground level. It is a major component of urban smog, forming when emissions from mobile and industrial sources interact with sunlight. Assessing the risk of adverse health effects from such exposures is difficult because only limited data are available on the actual ozone concentrations that people experience. Under the HEI ozone sampler program, three studies were designed to advance the development and testing of personal ozone samplers. The studies were conducted by Dr. Hackney and colleagues at Rancho Los Amigos Medical Center (Part I), Dr. Koutrakis and colleagues at the Harvard School of Public Health (Part II), and Dr. Yanagisawa from the Harvard School of Public Health (Part III). 

Effects of Carbon Monoxide on Isolated Heart Muscle Cells

Beatrice A Wittenberg
Jonathan B Wittenberg
December 1993
Research Report 62

Human exposure to carbon monoxide can occur from automobile emissions, industrial processes, sidestream or mainstream cigarette smoke, and poorly ventilated appliances such as space heaters and gas stoves. Most researchers consider the major mechanism for the toxicity of carbon monoxide to be its ability to compete with oxygen for binding to hemoglobin, the protein that transports oxygen through the bloodstream and releases it to cells and tissues.

Methods Development Toward the Measurement of Polyaromatic Hydrocarbon–DNA Adducts by Mass Spectrometry

Roger W Giese
Paul Vouros
October 1993
Research Report 61

Both environmental and genetic factors are believed to contribute to the multistage process that results in carcinogenesis. Therefore, determining the health risks associated with exposure to known and suspected carcinogenic chemicals is essential for informed decision-making by regulatory agencies. Dr. Roger W. Giese and colleagues at Northeastern University developed sensitive and specific techniques for measuring polycyclic aromatic hydrocarbon (PAH)-DNA adducts, a class of DNA adducts associated with exposure to constituents of diesel emissions and other combustion products.

Failure of Ozone and Nitrogen Dioxide to Enhance Lung Tumor Development in Hamsters

Hanspeter Witschi
Michael A Breider
Hildegard M Schuller
September 1993
Research Report 60

Ozone and nitrogen dioxide are highly reactive oxidant gases that are derived from the combustion of fossil fuels and the atmospheric transformation of these combustion products. A major unanswered question is whether or not exposure to oxidant air pollutants contributes to lung cancer. Dr. Witschi and colleagues at the University of California at Davis examined whether exposure to ozone or nitrogen dioxide enhances the development of tumors induced by the chemical carcinogen diethylnitrosamine (DEN), particularly neuroendocrine tumors, in the respiratory tract of hamsters.

Characterization of Particle- and Vapor-Phase Organic Fraction Emissions of a Heavy-Duty Diesel Engine Equipped with a Particle Trap and Regeneration Controls

Susan T Bagley
Linda D Gratz
David G Leddy
John H Johnson
July 1993
Research Report 56

Devices have been developed to reduce particle emissions from vehicles with diesel engines, such as a trap that filters the particles from the exhaust. Periodically, the trap is cleaned (regenerated) by electric heating, thereby burning the particles before they can clog the trap. There is concern that potentially harmful chemicals associated with the particles may be emitted from the trap during normal use and regeneration. Dr.

Nitrogen Dioxide and Respiratory Illness in Children, Part I: Health Outcomes, and Part II: Assessment of Exposure to Nitrogen Dioxide

Jonathan M Samet
William E Lambert
June 1993
Research Report 58-I & II

This publications contains two reports by Drs. Jonathan M. Samet, John D. Spengler, and colleagues, who conducted a prospective investigation of 1,205 healthy infants living in homes with gas or electric stoves in Albuquerque, NM. Nitrogen dioxide exposures were carefully estimated from repeated measurements in multiple locations in the subjects' homes throughout the entire 18-month observation period. Respiratory illnesses were monitored prospectively using a surveillance system based on daily parental diaries of respiratory signs and symptoms. Parental reports of illness episodes were validated in a subset of the population by comparison with clinical diagnoses and microbiological testing. Potential confounding factors that influence respiratory infections were reduced by selecting subjects whose parents did not smoke or intend to use day-care services outside the home.

Research Priorities for Mobile Air Toxics

Health Effects Institute
June 1993
Communication 2

Communication 2 provides information to decision makers on research that is potentially capable of narrowing uncertainties related to the health effects of specific air toxics. This report is based on the Mobile Air Toxics Workshop held in Monterey, CA, December 4–6 1992.

Do Electric or Magnetic Fields Cause Adverse Health Effects?

Health Effects Institute
June 1993
Special Report

HEI's Research Plan to Narrow the Uncertainties. This report of the HEI Electric and Magnetic Fields (EMF) Research Planning Committee presents a 5-7 year research program intended to clarify whether or not there are adverse health effects from exposure of the public to EMF from electric power transmission, machinery, or household appliances.