Publications

This page is a list of publications in reverse chronological order. Please use search or the filters to browse by research areas, publication types, and content types.

Displaying 201 - 210 of 293. Show 10 | 25 | 50 | 100 results per page.


Pulmonary Toxicity of Inhaled Diesel Exhaust and Carbon Black in Chronically Exposed Rats. Part III: Examination of Possible Target Genes

Steven A Belinsky
Charles E Mitchell
Kristen J Nikula
Deborah S Swafford
December 1995
Research Report 68-III

In Part III of this study, Dr. Belinsky and his associates at the Lovelace Biomedical and Environmental Research Institute examined lung tumors from rats that had inhaled high concentrations of diesel engine exhaust or carbon black particles (see Part I by Dr. Joe Mauderly). The investigators applied molecular biology techniques to measure mutations in selected genes in the DNA from the tumors.

DNA Adduct Formation and T-Lymphocyte Mutation Induction in F344 Rats Implanted with Tumorigenic Doses of 1,6-Dinitropyrene

Frederick A Beland
October 1995
Research Report 72

Dr. Beland and his associates at the University of Arkansas School of Medical Sciences developed an assay to measure mutations induced by dinitropyrenes, a class of diesel engine exhaust, in rats. The investigators analyzed the mutations in a selected gene in spleen T lymphocytes from rats treated with 1,6-dinitropyrene under conditions that induced lung tumors at the highest dose tested. They also examined DNA adduct levels in lung and liver tissues and in spleen lymphocytes and white blood cells.

Activation of Eicosanoid Metabolism in Human Airway Epithelial Cells by Products of Ozonolysis in Membrane Fatty Acids

George D Leikauf
Qiyu Zhao
Shaoying Zhou
Jeffrey Santrock
September 1995
Research Report 71

Dr. Leikauf and colleagues at the University of Cincinnati Medical Center examined the potential of the secondary products produced from the reaction of ozone with the fluids and the cell membrane of airway epithelial cells to cause biochemical effects. The investigators prepared aldehydes and hydroxyhydroperoxides of different carbon chain lengths. They tested these compounds and hydrogen peroxide in cultures of human airway epithelial cells grown from tissue explants.

Consequences of Prolonged Inhalation of Ozone on F344/N Rats: Collaborative Studies. Part VI: Background and Study Design

Gary A Boorman
Paul J Catalano
Bernard J Jacobson
Debra A Kaden
Paul W Mellick
Kathleen M Nauss
Lousie M Ryan
August 1995
Research Report 65-VI

In 1987, the Health Effects Institute entered into a partnership with the National Toxicology Program (NTP) to evaluate the effects of prolonged ozone exposure on F344/N rats. The NTP studies focused on carcinogenicity, while HEI supported eight studies that addressed the biochemical, functional, and structural endpoints and a biostatistical study that developed a sample allocation design and helped to integrate the research findings.

Particulate Air Pollution and Daily Mortality: The Phase I Report of the Particle Epidemiology Evaluation Project. Phase I.A: Replication and Validation of Selected Studies

Health Effects Institute
August 1995
Special Report

The Phase I.A Report of the Particle Epidemiology Evaluation Project. The Health Effects Institute began the Particle Epidemiology Evaluation Project in 1994 to evaluate the emerging epidemiologic evidence of a relation between particulate air pollution and daily mortality. In Phase I.A, Drs. Jonathan M. Samet and Scott L. Zeger and their colleagues at the Johns Hopkins University School of Hygiene and Public Health (1) reconstructed from original sources the data set for Philadelphia used in earlier studies and confirmed previous numerical results from analyzing these data; (2) developed an analytic approach (including new statistical methods) based on the Philadelphia data set; and (3) applied this approach to data sets for six locations: Philadelphia; Utah Valley; St. Louis, MO; Eastern Tennessee; Birmingham, AL; and Santa Clara County, CA.

Consequences of Prolonged Inhalation of Ozone on F344/N Rats: Collaborative Studies. Part XI: Integrative Summary

Paul J Catalano
Ling-Yi Chang
Jack R Harkema
Debra A Kaden
Jerold A Last
Paul W Mellick
William C Parks
Kent E Pinkerton
Bhandaru Radhakrishnamurthy
Louise M Ryan
John L Szarek
April 1995
Research Report 65-XI

In 1987, the Health Effects Institute entered into a partnership with the National Toxicology Program (NTP) to evaluate the effects of prolonged ozone exposure on F344/N rats. The NTP studies focused on carcinogenicity. HEI funded eight independent research studies, including investigations of lung biochemical constituents, structural and cellular changes, lung function, and nasal structure and function.

Diesel Exhaust: Critical Analysis of Emissions, Exposure, and Health Effects

Health Effects Institute
April 1995
Special Report

A Special Report of the Institute's Diesel Working Group. Diesel engine emissions have the potential to cause adverse health effects, including cancer and other pulmonary and cardiovascular diseases. However, it is difficult to distinguish the potential health risks attributable to exposure to diesel exhaust from those attributable to other air pollutants. For over a decade, HEI has supported a broad-based research program to evaluate the health risks of diesel emissions, including investigations of carcinogenesis, modeling studies, and emissions characterization. The purpose of this Special Report is to examine what is known, not known, and still uncertain about the health risks of exposure to diesel emissions.

Consequences of Prolonged Inhalation of Ozone on F344/N Rats: Collaborative Studies. Parts VIII and IX

Ling-Yi Chang
Kent E Pinkerton
March 1995
Research Report 65-VIII & IX

Ozone is a highly reactive gas that is a pervasive air pollutant at ground level. It is a major component of urban smog, forming when emissions from mobile and industrial sources interact with sunlight. In this report, two of studies and in the NTP/HEI Collaborative Ozone Project, were conducted to determine whether prolonged inhalation of ozone produces lasting effects on lung structure, potentially contributing to or aggravating chronic lung disease. Drs. Chang and Pinkerton and their respective colleagues investigated the effects of this prolonged ozone exposure on respiratory tract structure in healthy male and female F344/N rats. 

Consequences of Prolonged Inhalation of Ozone on F344/N Rats: Collaborative Studies. Part X: Robust Composite Scores Based on Median Polish Analysis

Paul J Catalano
John Rogus
Louise M Ryan
January 1994
Research Report 65-X

One major component of urban smog is ozone, a highly reactive gas that forms when emissions from mobile and industrial sources react chemically in the presence of sunlight.  One concern is that prolonged ozone exposure could cause noncancerous lung diseases such as fibrosis and emphysema. The NTP's bioassay project presented a unique opportunity for a collaboration between the HEI and the NTP.

Oxidant and Acid Aerosol Exposure in Healthy Subjects and Subjects with Asthma

Jane Koenig
Mark J Utell
November 1994
Research Report 70

In two separate studies, Drs. Koenig and Utell examined the effects of exposing healthy subjects and subjects with asthma to combined oxidant and acid pollutants. Each team of investigators conducted studies in which human volunteers received either combined or sequential exposures to oxidant gases and acid aerosols and standard pulmonary function tests were performed and symptoms were recorded. Dr. Koenig and colleagues exposed 28 adolescents with asthma to varying concentrations of ozone, nitrogen dioxide, and sulfuric acid. Dr. Utell and colleagues examined the effects of sequential exposures to sulfuric acid and ozone on pulmonary function in 30 subjects with asthma and 30 healthy subjects between the ages of 18 and 45.