Ozone-Induced Modulation of Airway Hyperresponsiveness in Guinea Pigs

Dr. Schlesinger and colleagues at the New York University School of Medicine used a well-established animal model of airway hyperresponsiveness (a heightened tendency of the bronchial airways to constrict) and allergic asthma to determine whether ozone can induce airway hyperresponsiveness or exacerbate existing airway hyperresponsiveness. Male and female guinea pigs were exposed to ozone concentrations comparable to levels to which humans are exposed during periods of ozone pollution. Some animals were sensitized to the allergen ovalbumin to induce hyperresponsiveness before or during ozone exposure. The investigators assessed airway hyperresponsiveness as well as biochemical and cellular measurements or makers of inflammation in lung fluids and tissue.