Ozone & Oxidants

This page has a list of publications and news articles related to Air Pollution - Ozone and Oxidants. Find more information about our research on Air Pollution.

Research Report 39
James S Ultman
Abdellaziz Ben-Jebria

This report describes a study by Drs. Ultman and Ben-Jebria to develop a chemiluminescent ozone analyzer and constructed an ozone bolus generator with the goal of using bolus concentration-response methods to noninvasively measure the longitudinal distribution of ozone absorption in human lungs. The analyzer was based on the chemiluminescent reaction between 2-methyl-2-butene and ozone. Validation of the system was performed in excised pig and sheep tracheas, and the resulting absorption coefficient was computed.

Research Report 38
Jerold A Last

This report describes a study by Dr. Last to investigate possible synergistic effects of multiple air pollutants on pulmonary measures in rats. Rats were exposed for 1-9 days to mixtures of O3 or NO2 and aerosols of sulfuric acid, ammonium sulfate, or sodium chloride, and to each pollutant individually. Responses were evaluated by various biochemical and morphometric analyses of lung tissue and lavage fluid. An additional preliminary experiment treated exposed rats in vivo with various free-radical scavengers to elucidate possible protective properties.

Research Report 22
Keith A Tanswell

This report addressed the hypothesis that hypertrophy of the lung after oxidant injury with ozone or oxygen is due to local generation of lung-specific growth factors. Dr. Tanswell exposed rats to either 85% oxygen, 1 ppm ozone, or air for up to two weeks while samples of plasma, lung washings, and lung tissue were periodically collected. These samples were tested for their effect on the DNA synthesis of purified populations of three major lung cell types (pneumocyte, fibroblast, and endothelial cell) in culture.

Research Report 14
Jane Koenig
William E Pierson
Susan Gayle Marshall
David S Covert
Michael S Morgan
Gerald van Belle

This report investigated whether asthmatic and healthy adolescents differ in their sensitivity to near-ambient concentrations of ozone and nitrogen dioxide. Dr. Koenig and colleagues exposed healthy and asthmatic participants to concentrations of 0.12 and 0.18 ppm ozone or 0.12 and 0.18 ppm nitrogen dioxide during rest or rest followed by moderate exercise.

Research Report 11
David A Johnson

Addressing the need for better assessment of human exposure to mobile source emissions, this report investigates proteinase inhibitor activity as a potential biomarker of oxidant exposure. In this study by Dr. Johnson, human participants were exposed to 0.5 ppm ozone for four hours on consecutive days and to concentrations ranging from 0.6-2 ppm nitrogen dioxide for three hours. Blood samples were obtained and the functional activity of the proteinase inhibitors, alpha-1-proteinase, and bronchial leukocyte proteinase was assessed.

Research Report 6
Deborah M Drechsler-Parks

Dr. Drechsler-Parks and colleagues at the Institute of Environmental Stress sought to examine the effects of nitrogen dioxide, ozone, and peroxyacetyl nitrate on metabolic and pulmonary function. Because it is possible that two or more pollutants could interact in ambient air and cause effects that could not be predicted from the effects observed with the individual pollutants, the investigators examined varying levels of different pollutants in 32 non-smoking men and women (8 men and 8 women 18-26 years of age and 8 men and 8 women 51-76 years of age).

Research Report 1
Marie A Amoruso

Acute hemolytic anemia is associated with a deficiency in glucose 6-phosphate dehydrogenase (G6PD), an X-linked inheritable characteristic. Hemolytic anemia is thought to be caused by a depletion of glutathione and other reducing compounds in red blood cells. Dr. Amoruso and colleagues sought to experimentally test the Calabrese hypothesis, which suggests that G6PD-deficient individuals may be at an increased risk of hemolysis during exposure to low levels of oxidants such as ozone.