Diesel Exhaust

This page has a list of publications and news articles related to Air Pollution - Diesel Exhaust. Find more information about our research on Air Pollution.

Research Report 19
Ronald K Wolff
Edward Barr
James A Bond
Arthur F Eidson
William C Griffith
Fletcher F Hahn
Jack R Harkema
Rogene F Henderson
Charles E Mitchell
Simon J Rothenberg
George M Shopp
James D Sun

This report assessed in rats the carcinogenicity of inhaled 1-nitropyrene, a compound frequently adsorbed to diesel particulate matter, and whether this effect is modified when 1-nitropyrene is associated with particles or irritant gases. Dr. Wolff and colleagues exposed rats to atmospheres containing 14C radiolabeled 1-nitropyrene alone or in combination with gallium oxide, sulfur dioxide, or both. After exposure, tissue samples were analyzed for radiolabel content to determine the tissue distribution of 1-nitropyrene and its metabolites.

Research Report 17
Veronica M Maher
Joe Dale Patton
J Justin McCormick

This report describes a study by Dr. Maher and colleagues to investigate the biological effects of nitropyrene compounds, found in diesel emission particulate, on diploid human fibroblasts in culture in order to better evaluate potential health effects. Diploid human fibroblasts from normal individuals and individuals with a genetic predisposition to cancer were studied and compared through a series of experiments.

Research Report 16
Charles M King

This report describes a study by Dr. King to investigate in rats the carcinogenic properties of nitropyrene and related compounds and how these compounds are metabolically activated in target tissues. Nitropyrenes and related nitroaromatics are of interest because of their ubiquity in diesel emissions and reported carcinogenicity.

Research Report 10

Dr. Yu's project addressed several important issues regarding improved quantification of dose from known concentrations of atmospheric particulate matter. By focusing first on a specific category of automotive-derived particles, diesel exhaust particulate, Dr. Yu was able to characterize those aerosol properties (such as the mass medican aerodynamic diameter and size distribution) that influence regional deposition. After formulating a mathematical deposition model, Dr.

Research Report 8
Joe L Mauderly
David E Bice
Robert L Carpenter
Nancy A Gillett
Rogene F Henderson
John A Pickrell
Ronald K Wolff

Previous research has reported that the lung development of animals exposed to oxidant gases early in life might be impaired, or that developing lungs might be more susceptible than adult lungs to inhaled toxicants. Dr. Mauderly and colleagues at the Lovelace Biomedical and Environmental Research Institute examined the age-related differences in the physiological responses of rats to inhaled automotive emissions. The younger group was exposed during gestation and through the age of six months, while the older group was exposed between the age of six and twelve months.

Research Report 7
John D Groopman

Research Report 7 describes a study that attempted to produce monoclonal antibodies to DNA adducts of nitropyrene that could be used to study the mechanism of nitropyrene-induced carcinogenesis or develop analytical techniques for monitoring exposed populations. Dr. Groopman immunized mice against nitropolycyclic aromatic hydrocarbons conjugated with a carrier protein to study the progression of immune response. Dr. Groopman injected four antigens into groups of BALB/c, AJ, and NZB mice. Two of the antigens failed to produce any immune response.

Research Report 5
Susan T Bagley
Linda D Dorie
David G Leddy
John H Johnson

Dr. Bagley and colleagues at Michigan Technical University examined the chemical mutagenic effects of a ceramic particle trap on a medium-duty diesel engine. Diesel exhaust particles and vapor phase samples were collected from diluted (15:1) exhaust of a 10.4L displacement Caterpillar 3208 engine. The investigators compared uncontrolled (baseline) emissions with exhaust that had been modified by the use of an uncatalyzed monolithic ceramic trap.

Research Report 4
Frederick A Beland

Nitrated polycyclic aromatic hydrocarbons (PAHs) are common environmental contaminants that often contain genotoxic activity. Dinitropyrenes are a class of PAHs that are associated with diesel exhaust. In this study, Dr. Beland and colleagues at the University of Arkansas for Medical Sciences sought to determine what factors contribute to the extreme genotoxicity of dinitropyrenes in bacteria and to establish if the same factors were important for the genotoxicity of dinitropyrenes in mammalian systems.

Research Report 2
James A Bond
Michele A Medinsky
James D Sun

Nitro-polynuclear aromatic hydrocarbons, including 1-nitropyrene, are constituents of diesel exhaust. Previous fractionation research has suggested that 1-nitropyrene and various dinitropyrenes may account for 20-50% of the total mutagenicity in the diesel particle extract (DPE). Dr. Bond and colleagues at the Inhalation Toxicology Research Institute examined the biological fate of inhaled 14C-1-nitropyrene (NP) in Fischer-344 rats.