Diesel Exhaust

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An Investigation into the Effect of a Ceramic Particle Trap on the Chemical Mutagens in Diesel Exhaust

Research Report 5

Susan T Bagley

Linda D Dorie

David G Leddy

John H Johnson

January 1987

Topics:

Diesel Exhaust

Dr. Bagley and colleagues at Michigan Technical University examined the chemical mutagenic effects of a ceramic particle trap on a medium-duty diesel engine. Diesel exhaust particles and vapor phase samples were collected from diluted (15:1) exhaust of a 10.4L displacement Caterpillar 3208 engine. The investigators compared uncontrolled (baseline) emissions with exhaust that had been modified by the use of an uncatalyzed monolithic ceramic trap.

The Metabolic Activation and DNA Adducts of Dinitropyrenes

Research Report 4

Frederick A Beland

August 1986

Topics:

Diesel Exhaust

Nitrated polycyclic aromatic hydrocarbons (PAHs) are common environmental contaminants that often contain genotoxic activity. Dinitropyrenes are a class of PAHs that are associated with diesel exhaust. In this study, Dr. Beland and colleagues at the University of Arkansas for Medical Sciences sought to determine what factors contribute to the extreme genotoxicity of dinitropyrenes in bacteria and to establish if the same factors were important for the genotoxicity of dinitropyrenes in mammalian systems.

Disposition and Metabolism of Free and Particle-Associated Nitropyrenes After Inhalation

Research Report 2

James A Bond

Michele A Medinsky

James D Sun

January 1986

Topics:

Diesel Exhaust

Nitro-polynuclear aromatic hydrocarbons, including 1-nitropyrene, are constituents of diesel exhaust. Previous fractionation research has suggested that 1-nitropyrene and various dinitropyrenes may account for 20-50% of the total mutagenicity in the diesel particle extract (DPE). Dr. Bond and colleagues at the Inhalation Toxicology Research Institute examined the biological fate of inhaled 14C-1-nitropyrene (NP) in Fischer-344 rats.