Understanding the Early Biological Effects of Isoprene-Derived Particulate Matter Enhanced by Anthropogenic Pollutants

Research Report 198,

Research Report 198 describes a study by Dr. Jason D. Surratt at UNC, Chapel Hill, and his colleagues to evaluate the toxicity of fine particulate matter formed from the photochemical oxidation of isoprene in a chamber. Isoprene is an abundant volatile organic compound emitted by trees and other biogenic sources; information about its potential role in PM toxicity is lacking. The investigators compared the oxidative property and biological responses of various aerosol mixtures, using isoprene as a “seed” molecule, as well as isoprene oxidation products and oxygen radicals. This study was funded by HEI’s Walter A. Rosenblith New Investigator Award