Publications

This page is a list of publications in reverse chronological order. Please use search or the filters to browse by research areas, publication types, and content types.

Displaying 26 - 50 of 289. Show 10 | 25 | 50 | 100 results per page.


Diesel Emissions and Lung Cancer: An Evaluation of Recent Epidemiological Evidence for Quantitative Risk Assessment

HEI Diesel Epidemiology Panel
November 2015
Special Report 19

Special Report 19 contains the intensive review and analysis of the newest studies of mine and truck workers exposed to older diesel engine exhaust conducted by an Expert Panel appointed by the HEI Board of Directors. In its report, HEI's Diesel Epidemiology Panel concluded that the studies are well prepared and are useful for applying the data to calculate the cancer risk due to exposure to diesel exhaust.

Update Fall 2015

Health Effects Institute
November 2015
Newsletter

This newsletter reports on the approval of new HEI studies to examine potential health effects of low-level pollution; the completion of a review of diesel exhaust studies (Special Report 19) by an HEI-appointed panel; and WHO's plans to update global air quality guidelines. In addition, it announces the publication of an HEI report taking a closer look at exposure to PM2.5 and its composition and a report evaluating rapid heart rhythm changes after exposure to PM. HEI also announces the recipient of the 2015 Walter A. Rosenblith New Investigator Award and the appointment of three new HEI Research Committee members.

Strategic Research Agenda on the Potential Impacts of 21st Century Oil and Natural Gas Development in the Appalachian Region and Beyond

HEI Special Scientific Committee on Unconventional Oil and Gas Development in the Appalachian Basin
November 2015
Strategic Research Agenda

Unconventional oil and natural gas development is a driving force behind significant economic and energy policy shifts in the United States and the world today. Technological advances in development are substantially increasing energy supplies, while at the same time outpacing the scientific research that can answer questions about the development’s potential effects.

Update Summer 2015

Health Effects Institute
August 2015
Newsletter

This issue reports on the publication of an Executive Summary highlighting ACES new-technology diesel results, which describes significant improvements in new diesel engines; a conference showcasing HEI science and emerging research opportunities; interest worldwide in ACES findings; how HEI staff are communicating results; the status of the oil and gas research agenda being drafted by HEI; and the status of the MOSES testing of ozone study subjects.

HEI Investigators' Guide. Preparing the Final Report

Health Effects Institute
August 2015
Guide for Authors

The Investigators' Guide contains important information for HEI-funded investigators who are getting ready to write the Final Report for their study. The Guide introduces HEI's review, editing, and publication process and lists requirements for submission of the report. The Guide also contains detailed instructions on reference and text styles, tables and illustrations, and submission of electronic art.

Development of Statistical Methods for Multipollutant Research

Brent A Coull
et al.
Eun Sug Park
et al.
June 2015
Research Report 183, Parts 1 and 2

This report contains two studies, by Drs. Brent A Coull and Eun Sug Park and their colleagues, and a Commentary discussing each study individually, as well as an Integrative Discussion of the two. 
Part 1. Statistical Learning Methods for the Effects of Multiple Air Pollution ConstituentsBrent A. Coull et al.
Part 2. Development of Enhanced Statistical Methods for Assessing Health Effects Associated with an Unknown Number of Major Sources of Multiple Air Pollutants. Eun Sug Park et al. 

Immune Effects of Episodic Ozone and Particulate Matter Exposure During Postnatal Development

Fern Tablin
Lisa Miller
Philip Kass
June 2015
Unpublished Report

This unpublished report describes a two-year study to evaluate the effect of exposure to particulate matter and ozone on immune function in nonhuman primates (infant rhesus macaques) during early life. The investigators conducted a panel study that took advantage of "natural" exposures in the outdoor nonhuman primate colony maintained at the California National Primate Center, a research unit of the University of California–Davis.

Update Spring 2015

Health Effects Institute
May 2015
Newsletter

Contents: HEI's Strategic Plan for 2015–2020 Now Under Way;  Greenbaum Chairs NRC Review of U.S. Climate, Health Assessment; O'Keefe Closes Out Successful Run on Key Air Advisory Committee; Communicating Results - HEI Science Highlighted at EPA Workshops HEI in the News - Wide Audience for ACES Findings; Novel Statistical Methods for Studying Pollutant Mixtures; Journal Spotlights NPACT Studies; Eyes on the Future - HEI Sponsors Meet with Research Committee to Discuss the Path Forward;  Walter A. Rosenblith New Investigator Award Announced

HEI's Strategic Plan 2015-2020

Health Effects Institute
May 2015
Strategic Plan

HEI has launched its Strategic Plan for Understanding the Health Effects of Air Pollution for the coming five years, guiding HEI’s direction based on extensive input from sponsors, the scientific community, environmental organizations, and others. The Plan seeks to produce timely and credible science to inform key decisions with one overarching theme: informing decisions on air quality and on climate-driven technology for 2015-2020…and beyond.

Update Winter 2015

Health Effects Institute
February 2015
Newsletter

Contents: Major Report on Newest Diesel Engines - No Evidence of Lung Cancer in Rats after Lifetime Exposure to New-Technology Diesel Exhaust; Sign Up Now for HEI's Annual Conference 2015 in Philadelphia in May; Nominations for Committee Membership Invited; Progress on Strategic Research Plan for Oil and Gas; Better Air Quality Meeting in Sri Lanka

Advanced Collaborative Emissions Study (ACES): Lifetime Cancer and Non-Cancer Assessment in Rats Exposed to New-Technology Diesel Exhaust

Jacob D McDonald
Jeffrey C Bemis
Lance M Hallberg
Daniel J Conklin
January 2015
Research Report 184

This report describes four studies conducted as a single phase (Phase 3B) of HEI's Advanced Collaborative Emissions Study (ACES) program, which was designed to evaluate the emissions and health changes resulting from substantially improved diesel engines required under the U.S. EPA 2007–2010 Heavy Duty Diesel Rule. These studies were conducted by Drs. Jacob D. McDonald of the Lovelace Respiratory Research Institute, Albuquerque, New Mexico, Jeffrey C. Bemis of Litron Laboratories, Rochester, New York, Lance M. Hallberg of the University of Texas Medical Branch, Galveston, Texas, and Daniel J. Conklin, University of Louisville, Kentucky.

Synergistic Effects of Particulate Matter and Substrate Stiffness on Epithelial-to-Mesenchymal Transition

Thomas H Barker
Marilyn M Dysart
Ashley C Brown
Alison M Douglas
Vincent F Fiore
Armistead G Russell
November 2014
Research Report 182

This report is a study focused on lung tissue repair processes after inflammation and injury resulting from exposure to particulate matter (PM) from combustion sources. Dr. Thomas H. Barker of Georgia Institute of Technology, a recipient of HEI's Walter A. Rosenblith New Investigator Award, and his colleagues tested the hypotheses that alveolar epithelial cells grown on substrates of increasing stiffness would transition to mesenchymal cells — an early step along the pathway to fibrosis — and that the addition of fine PM would enhance these effects.

Update Fall 2014

Health Effects Institute
October 2014
Newsletter

Contents: Setting a Course for 2020: The HEI Strategic Plan; RFA Seeks New Epidemiologic Studies; HEI Launches New International Project // Group of Experts Will Estimate Global Burden of Disease from Specific Major Air Pollution Sources; Communicating Results of Research; How PM May Affect Epithelial Cell Differentiation; Progress on Major Ozone Study; Panel Tours Gas Well Sites

Update Summer 2014

Health Effects Institute
August 2014
Newsletter

Contents: Conference Eyes Future of Air Pollution Research, Policy; Leading Health Expert to Chair Review Committee; Workshop on Unconventional Oil and Gas Development; Developing New Models for Ultrafine Particles and Air Toxics Exposures; Sharing Insight from NPACT Setting Research Priorities (Research Planning Meeting); HEI in the News; HEI Strategic Plan 2015-2020 Taking Shape

Development and Application of an Aerosol Screening Model for Size-Resolved Urban Aerosols

Charles O Stanier
Sang-Rin Lee
June 2014
Research Report 179

This report describes a study in which a model to simulate the dispersion of ultrafine particles near roadways was developed and tested. Understanding what happens to ultrafines near roadways – and how that influences exposure – is a key area that HEI's Perspectives 3 on ultrafines (2013) identified. Dr. Charles Stanier at the University of Iowa–Iowa City, a recipient of HEI's Walter A.

Personal Exposure to Mixtures of Volatile Organic Compounds: Modeling and Further Analysis of the RIOPA Data

Stuart Batterman
Feng-Chiao Su
Shi Li
Bhramar Mukherjee
Chunrong Jia
June 2014
Research Report 181

This report describes a study to identify factors that influence exposure to volatile organic compounds (VOCs) and VOC mixtures. Dr. Stuart Batterman at the University of Michigan–Ann Arbor and colleagues used the extensive data that HEI posted on the Web from the Relationships of Indoor, Outdoor, and Personal Air (RIOPA) study (HEI Research Report 130 Parts I and II), and data from the National Health and Nutrition Examination Survey (NHANES), to characterize exposure distributions for 15 VOCs, with an emphasis on high concentrations. Factors examined included geographic location, weather, characteristics of participants' homes, and specific activities, such as pumping gas.

Update Spring 2014

Health Effects Institute
May 2014
Newsletter

Contents: HEI Research Committee Welcomes a New Epidemiologist; Ultrafine Particles Study Focuses on School Buses; New Initiative Addresses Unconventional Oil and Gas Development; A Growing Audience for HEI's Web Site; Sponsors, Research Committee Meet in Boston;  Assessing Diesel Epidemiology Studies; Walter A. Rosenblith New Investigator Award

Characterizing Ultrafine Particles and Other Air Pollutants In and Around School Buses

Yifang Zhu
Qunfang Zhang
March 2014
Research Report 180

This report describes a study that assessed levels of ultrafine particles and other pollutants around diesel engine school buses and identified factors contributing to those levels. Dr. Yifang Zhu at the University of California–Los Angeles, a recipient of HEI's Walter A. Rosenblith New Investigator Award, measured pollutant levels in and around school buses while driving, while idling, before and after retrofitting with a diesel particle filter and/or oxidation catalyst, and before and after installing an in-cabin filtration system.

Update Winter 2014

Health Effects Institute
February 2014
Newsletter

Contents: ACES Phase 2 Study Shows Dramatic Reductions in Emissions from Newer Diesel Engines; Annual Conference in D.C. Area Will Spotlight Science to Inform the Future; HEI Hosts Diesel Epidemiology Workshop; Making Data on Air Pollution and Health Accessible;  New Funding Opportunities: Traffic Related Exposure Studies / HEI Seeks Research on Non-Tailpipe and Tailpipe Emissions Near Urban Roads and in Tunnels; Window on Tomorrow: Building the HEI Strategic Plan 2015–2020

New Statistical Approaches to Semiparametric Regression with Application to Air Pollution Research

James M Robins
Peng Zhang
Rajeev Ayyagari
Roger Logan
Eric Tchetgen Tchetgen
Lingling Li
Thomas Lumley
Aad van der Vaart
November 2013
Research Report 175

This report describes semiparametric methods for epidemiologic investigations of the short-term effects of air pollution on health, intended specifically to improve the reliability of point estimates and confidence intervals. Dr. James Robins of the Harvard School of Public Health and colleagues developed the new methods, used simulations to compare them with other methods, and applied them to a large epidemiologic data set from the National Morbidity, Mortality, and Air Pollution Study (NMMAPS) to assess their effectiveness. The report is accompanied by a short editorial to assist the reader in understanding this study and its contributions to epidemiologic methods for air pollution.

Update Fall 2013

Health Effects Institute
November 2013
Newsletter

Contents: HEI NPACT Studies Examine Effects of PM Sources and Components; New Studies Aim to Improve Knowledge of Exposure to Traffic; New Statisticians for the Research and Review Committees; HEI Investigator Wins Friedlander Award; Scientists Share Global Perspectives at ISEE Conference; O'Keefe Delivers Inaugural Address at Major Emissions Control Meeting in Delhi

National Particle Component Toxicity (NPACT) Initiative: Integrated Epidemiologic and Toxicologic Studies of the Health Effects of Particulate Matter Components

Morton Lippmann
Lung Chi Chen
Terry Gordon
Kazuhiko Ito
George D Thurston
October 2013
Research Report 177

This report describes the results of a study of long-term effects of PM components in the American Cancer Society's Cancer Prevention Study II cohort; a time-series study of short-term effects of PM components on cardiovascular and other diseases in people living in 150 U.S. cities; and two toxicologic studies in animals exposed by inhalation to concentrated ambient particles, and in animals and human cells exposed to particles collected on filters from five different airsheds across the United States. This report, along with Research Report 178 (Vedal et al.), is one of HEI's National Particle Component Toxicity (NPACT) studies, which describe the most systematic multidisciplinary studies to date to investigate the health effects of PM components in humans and animal models at locations across the United States where the effects of PM sources and components may differ. The report includes a Commentary and a Synthesis by the NPACT Review Panel.

National Particle Component Toxicity (NPACT) Initiative Report on Cardiovascular Effects

Sverre Vedal
Matthew J Campen
Jacob D McDonald
Joel D Kaufman
Timothy V Larson
Paul D Sampson
Lianne Sheppard
Christopher D Simpson
Adam A Szpiro
October 2013
Research Report 178

This report describes the results of two cohort studies of long-term effects of PM components on subclinical and clinical markers of cardiovascular diseases and a toxicologic study in which animals were exposed to mixtures of vehicle engine emissions and non-vehicular PM and analyzed for vascular effects. Section 3 contains an integrated discussion of the studies. This report, along with Research Report 177 (Lippmann et al.), is one of HEI's National Particle Component Toxicity (NPACT) studies, which describe the most systematic multidisciplinary studies to date to investigate the health effects of PM components in humans and animal models at locations across the United States where the effects of PM sources and components may differ. The report includes a Commentary and a Synthesis by the NPACT Review Panel.

Effect of Air Pollution Control on Mortality and Hospital Admissions in Ireland

Douglas W Dockery
David Q Rich
Patrick G Goodman
Luke Clancy
Pamela Ohman-Strickland
Prethibha George
Tania Kotlov
July 2013
Research Report 176

This report revisits an earlier study of the air pollution and health impacts of a coal ban in Dublin, Ireland, and then extends the analysis to coal bans in 11 additional Irish cities. Dr. Douglas W. Dockery of the Harvard School of Public Health and colleagues evaluated changes in black smoke and sulfur dioxide concentrations for the 5 years before and after the coal bans and examined how those changes related to mortality and hospitalization rates in the counties affected by the bans, as compared with other counties where coal bans were not implemented. They also included in their analysis other trends in health and social factors that were occurring at the same time.

Update Summer 2013

Health Effects Institute
July 2013
Newsletter

Contents: Annual Conference Showcases HEI's Scientific Program; Did the Irish Coal Bans Improve Air Quality and Health? Novel Approaches to Analyzing Health Effects Data; Board Seeks New Review Committee Chair; HEI Moving to Improve the Way it Communicates; Expert Group Conducts Peer Review of ACES Pathology Results