Publications

This page is a list of publications in reverse chronological order. Please use search or the filters to browse by research areas, publication types, and content types.

Displaying 101 - 110 of 295. Show 10 | 25 | 50 | 100 results per page.


Genotoxicity of 1,3-Butadiene and Its Epoxy Intermediates

Vernon E Walker
Dale M Walker
Quanxin Meng
Jacob D McDonald
Bobby R Scott
Steven K Seilkop
David J Claffey
Patricia B Upton
Mark W Powley
James A Swenberg
Rogene F Henderson
August 2009
Research Report 144

This report describes a study to evaluate genotoxic effects of exposure to 1,3-butadiene and its metabolites. 1,3-Butadiene is classified as a human carcinogen via inhalation, but risk assessment is complicated due to differences in metabolism between mice and rats and between males and females. Dr. Walker and colleagues studied mutagenicity in rats and mice of both genders, with a focus on evaluating stereoisomers of 1,3-butadiene metabolites and low exposure concentrations.

Measurement and Modeling of Exposure to Selected Air Toxics for Health Effects Studies and Verification by Biomarkers

Roy M Harrison
Juana Maria Delgado-Saborit
Stephen J Baker
Noel Aquilina
Claire Meddings
Stuart Harrad
Ian Matthews
Sotiris Vardoulakis
H Ross Anderson
June 2009
Research Report 143

This report describes a study to develop detailed personal exposure models that take various microenvironments into account. To develop the models, Dr. Harrison and colleagues made repeated measurements of exposure to selected air toxics for each of 100 healthy adult nonsmoking participants residing in urban, suburban, and rural areas of the United Kingdom expected to have different traffic exposures.

Extended Follow-Up and Spatial Analysis of the American Cancer Society Study Linking Particulate Air Pollution and Mortality

Daniel Krewski
Michael Jerrett
Richard T Burnett
Renjun Ma
Edward Hughes
Yuanli Shi
Michelle C Turner
C Arden Pope III
George Thurston
Eugenia E Calle
Michael J Thun
et al.
May 2009
Research Report 140

This report describes a recent analysis of the original ACS cohort, a large ongoing prospective study of mortality in adults that started in 1982 and has played a central role in the setting of National Ambient Air Quality Standards for fine particulate matter pollution in the U.S. as well as assessments of benefits from PM reduction worldwide. The new study describes for the first time work by Dr.

Air Pollution Effects on Ventricular Repolarization

Robert L Lux
C Arden Pope III
May 2009
Research Report 141

This report describes a study to explore novel electrocardiogram (ECG) parameters to improve our understanding of how air pollution may affect cardiovascular health. Drs. Robert Lux and Arden Pope used ECGs obtained in a previous study by Dr. Pope that found a decrease in heart rate variability associated with increased levels of particulate matter, and analyzed them for changes in novel parameters of another important potential change - ventricular repolarization.

Effects of Long-Term Exposure to Traffic-Related Air Pollution on Respiratory and Cardiovascular Mortality in the Netherlands: The NLCS-AIR Study

Bert Brunekreef
Rob Beelen
Gerard Hoek
Leo Schouten
Sandra Bausch-Goldbohm
Paul Fischer
Ben Armstrong
Edward Hughes
Michael Jerrett
Piet van den Brandt
March 2009
Research Report 139

Research Report 139 describes a study in the Netherlands using data from the ongoing Netherlands Cohort Study (NLCS) on diet and cancer. The study is one of the first to systematically assess longer term exposure and mortality in a well characterized European population; it followed a pilot study of 5000 adults randomly selected from the NLCS cohort conducted by the same team of investigators. For the current study, Dr.

The Influence of Improved Air Quality on Mortality Risks in Erfurt, Germany

Annette Peters
Susanne Breitner
Josef Cyrys
Matthias Stölzel
Mike Pitz
Gabriele Wölke
Joachim Heinrich
Wolfgang Kreyling
Helmut Küchenhoff
H-Erich Wichmann
February 2009
Research Report 137

Research Report 137, The Influence of Improved Air Quality on Mortality Risks in Erfurt, Germany, is the first study to come out of HEI's program on the health impact of regulatory and other actions to improve air quality, known as accountability. The report describes sweeping changes in the economy and energy use that occurred in the former East Germany after the 1990 reunification as a result of stricter environmental controls and modernization of industry, transportation, and household heating. Dr.

Health Effects of Real-World Exposure to Diesel Exhaust in Persons with Asthma

Junfeng (Jim) Zhang
James E McCreanor
Paul Cullinan
Kian Fan Chung
Pamela Ohman-Strickland
In-Kyu Han
Lars Järup
Mark J Nieuwenhuijsen
February 2009
Research Report 138

Research Report 138, Health Effects of Real-World Exposure to Diesel Exhaust in Persons with Asthma, is one part of HEI's larger program on the role of particles in exacerbating asthma and other allergic diseases. This report describes a study to evaluate how inhaling air with a high concentration of diesel exhaust from vehicular traffic while walking on a busy street in Central London might affect people who had either mild or moderate asthma. Dr.

Uptake and Inflammatory Effects of Nanoparticles in a Human Vascular Endothelial Cell Line

Ian M Kennedy
Dennis Wilson
Abdul I Barakat
January 2009
Research Report 136

Research Report 136, Uptake and Inflammatory Effects of Nanoparticles in a Human Vascular Endothelial Cell Line, is one part of HEI's larger program on the health effects of particulate matter and its various components. This report describes a one-year study to evaluate which physicochemical characteristics of metal nanoparticles may contribute to their toxicity.

Mechanisms of Particulate Matter Toxicity in Neonatal and Young Adult Rat Lungs

Kent E Pinkerton
Yamei Zhou
Caiyun Zhong
Kevin R Smith
Stephen V Teague
Ian M Kennedy
Margaret G Ménache
October 2008
Research Report 135

Research Report 135 describes a study to determine whether the biologic response to inhaled ultrafine particles depends on particle composition. Neonatal and young adult rats were exposed to laboratory-generated ultrafine metal particles, either alone or in combination with soot, and their lungs examined for oxidative stress, inflammation, and injury.

Public Health and Air Pollution in Asia (PAPA): Key Results from Bangkok, Hong Kong, Shanghai, and Wuhan

Health Effects Institute
October 2008
Communication 13

The September issue of Environmental Health Perspectives published the first systematic presentation of the HEI-funded PAPA studies in Bangkok, Hong Kong, Shanghai, and Wuhan, as well as a combined analysis and accompanying editorial. These articles have been reprinted and are currently available as HEI Communication 13. The detailed studies and accompanying HEI commentaries will be published by the Institute this spring.