Publications

This page is a list of publications in reverse chronological order. Please use search or the filters to browse by research areas, publication types, and content types.

Displaying 91 - 100 of 293. Show 10 | 25 | 50 | 100 results per page.


Development and Application of a Sensitive Method to Determine Concentrations of Acrolein and Other Carbonyls in Ambient Air

Thomas M Cahill
M Judith Charles
Vincent Y Seaman
May 2010
Research Report 149

This report describes a study by Dr. Thomas Cahill and colleagues to create and evaluate a new method to measure acrolein and other volatile carbonyls present at low concentrations in ambient air. Acrolein is an important aldehyde that is very difficult to measure accurately, so developing better methods for measuring levels and exposure is critical to better risk assessment for the chemical. The investigators developed a sampler that traps acrolein using sodium bisulfite in an aqueous medium.

Atmospheric Transformation of Diesel Emissions

Barbara Zielinska
Shar Samy
Jacob D McDonald
JeanClare Seagrave
April 2010
Research Report 147

This report describes a study by Dr. Barbara Zielinska and colleagues to investigate the changes that fresh diesel emissions undergo when they are mixed with ambient air, due to reactions with sunlight and other pollutants. The investigators also evaluated how those changes may affect the toxic properties of diesel emissions. The study used a relatively new (2003 model) light duty diesel engine (although not one with a diesel filter) and provides insight into the complexity of diesel exhaust composition in the real world.

Impact of Improved Air Quality During the 1996 Summer Olympic Games in Atlanta on Multiple Cardiovascular and Respiratory Outcomes

Jennifer L Peel
Mitchel Klein
W Dana Flanders
James A Mulholland
Paige E Tolbert
April 2010
Research Report 148

This report is the latest in HEI's program of studies to assess the health impacts of air quality actions. Research Report 148 describes a study to evaluate the effect of a short-term, temporary intervention to reduce traffic congestion during the 1996 Summer Olympic Games in Atlanta, Georgia. A previous study had shown a decrease in acute care visits for pediatric asthma and a concomitant decrease in concentrations of ozone, particulate matter, and carbon monoxide.

Traffic-Related Air Pollution: A Critical Review of the Literature on Emissions, Exposure, and Health Effects

Health Effects Institute
January 2010
Special Report 17

A Special Report of the Institute's Panel on the Health Effects of Traffic-Related Air Pollution. This report is the most comprehensive and systematic review to date of the scientific literature on emissions, exposure, and health effects from traffic-related air pollution. It includes conclusions about the populations exposed around major roads, the associations between exposure to air pollution from traffic and human health, and important remaining data gaps. Compared with the initial pre-print version released in May 2009, this final version has undergone data verification and editorial changes; however, the overall conclusions did not change.

The Role of T Cells in the Regulation of Acrolein-Induced Pulmonary Inflammation and Epithelial-Cell Pathology

Michael T Borchers
Scott C Wesselkamper
Hitesh Deshmukh
Erin Beckman
Mario Medvedovic
Maureen Sartor
George D Leikauf
December 2009
Research Report 146

This report describes a study to investigate the role of two subpopulations of T cells in the airway response to inhaled acrolein, a toxic pollutant in ambient air, which US EPA's National Air Toxics Assessment has identified as having broad effects. Dr. Michael Borchers and colleagues measured inflammation and injury in response to acrolein in the lungs of mice that are genetically deficient in the specific T-cell subpopulations. He also measured changes in gene expression in the T-cell subpopulations after acrolein exposure. This study was funded under the Walter A.

Effects of Concentrated Ambient Particles and Diesel Engine Exhaust on Allergic Airway Disease in Brown Norway Rats

Jack R Harkema
James G Wagner
Norbert E Kaminski
Masako Morishita
Gerald J Keeler
Jacob D McDonald
Edward G Barrett
November 2009
Research Report 145

This report describes a study to investigate the suggested association between exposure to traffic-derived pollution and increases in symptoms of airway diseases, including exacerbation of asthma. Dr. Jack Harkema and colleagues assessed the effects of two pollutant mixtures, concentrated ambient particles (CAPs) and diesel exhaust, on airway inflammatory and allergic responses in a rodent model of asthma. The study was one part of an HEI 3-study program of animal and human research on these important questions.

Air Pollution and Health: A European and North American Approach

Klea Katsouyanni
Jonathan M Samet
H Ross Anderson
Richard Atkinson
Alain Le Tertre
Sylvia Medina
Evangelia Samoli
Giota Touloumi
Richard T Burnett
Daniel Krewski
Timothy Ramsay
Francesca Dominici
Roger D Peng
Joel Schwartz
Antonella Zanobetti
October 2009
Research Report 142

This report describes a unique collaboration among investigators from Europe, the United States, and Canada using existing data from three geographic areas and supported by HEI in collaboration with the European Commission. APHENA offered a large and diverse data set with which to address methodological as well as scientific issues about the relationships between PM10, ozone, and mortality and morbidity that were the subject of lively debates at the time the project was launched. 

HEI’s Research Program on the Impact of Actions to Improve Air Quality: Interim Evaluation and Future Directions

Annemoon M van Erp
Aaron J Cohen
September 2009
Communication 14

Communication 14, HEI's Research Program on the Impact of Actions to Improve Air Quality: Interim Evaluation and Future Directions, provides an overview of progress to date in HEI's Accountability program by evaluating nine studies that HEI has funded to assess actions that improve air quality. HEI's Accountability Research Program was initiated to assess the extent to which the predicted health benefits of new regulations have occurred.

Genotoxicity of 1,3-Butadiene and Its Epoxy Intermediates

Vernon E Walker
Dale M Walker
Quanxin Meng
Jacob D McDonald
Bobby R Scott
Steven K Seilkop
David J Claffey
Patricia B Upton
Mark W Powley
James A Swenberg
Rogene F Henderson
August 2009
Research Report 144

This report describes a study to evaluate genotoxic effects of exposure to 1,3-butadiene and its metabolites. 1,3-Butadiene is classified as a human carcinogen via inhalation, but risk assessment is complicated due to differences in metabolism between mice and rats and between males and females. Dr. Walker and colleagues studied mutagenicity in rats and mice of both genders, with a focus on evaluating stereoisomers of 1,3-butadiene metabolites and low exposure concentrations.

Measurement and Modeling of Exposure to Selected Air Toxics for Health Effects Studies and Verification by Biomarkers

Roy M Harrison
Juana Maria Delgado-Saborit
Stephen J Baker
Noel Aquilina
Claire Meddings
Stuart Harrad
Ian Matthews
Sotiris Vardoulakis
H Ross Anderson
June 2009
Research Report 143

This report describes a study to develop detailed personal exposure models that take various microenvironments into account. To develop the models, Dr. Harrison and colleagues made repeated measurements of exposure to selected air toxics for each of 100 healthy adult nonsmoking participants residing in urban, suburban, and rural areas of the United Kingdom expected to have different traffic exposures.