Publications

This page is a list of publications in reverse chronological order. Please use search or the filters to browse by research areas, publication types, and content types.

Displaying 201 - 210 of 322. Show 10 | 25 | 50 | 100 results per page.


The Health Effects of Fine Particles: Key Questions and the 2003 Review

Health Effects Institute
October 1999
Communication 8
Report of the Joint Meeting of the EC and HEI, held in Brussels, Belgium, January 14–15 1999. The following topics were discussed: What Are People Exposed To and Where Do Particles Come From? What Is Known About the Health Effects of PM? What New Research Results Are Emerging? and Outstanding Questions and Gaps for 2003 and Beyond.

Reproductive and Offspring Developmental Effects Following Maternal Inhalation Exposure to Methanol in Nonhuman Primates

Thomas Burbacher
October 1999
Research Report 89

In an effort to improve air quality and decrease dependence on petroleum, alternative fuels such as methanol have been considered to substitute for gasoline or diesel fuel. Methanol is also a candidate to provide the hydrogen for fuel cells. Before people are exposed to increased concentrations of methanol, the potential health effects of such exposures require study. Dr. Burbacher and colleagues of the University of Washington studied the effects of long-term exposure to methanol vapors on metabolism and reproduction in adult female monkeys (Macaca fascicularis) and developmental effects in their offspring, who were exposed prenatally to methanol. 

Morphometric Analysis of Alveolar Responses of F344 Rats to Subchronic Inhalation of Nitric Oxide

Robert R Mercer
September 1999
Research Report 88

In a follow-up study to previous research, Dr. Mercer and colleagues at Duke University exposed three groups of rats continuously for six weeks to 2 or 6 ppm nitric oxide (NO) or to filtered air to learn more about the toxicity of NO so as to compare it with two other important oxidants, ozone and nitrogen dioxide (NO2). At the end of the exposure period he used an electron microscope to measure the number of holes in the alveolar septa and to observe other structural changes, such as in the surface area and the number and type of other abnormalities in the alveolar septa.

Development of Liquid Chromatography–Electrospray Ionization–Tandem Mass Spectrometry Methods for Determination of Urinary Metabolites of Benzene in Humans

Assieh A Melikian
Min Meng
Ray O’Connor
Peifeng Hu
Seth M Thompson
June 1999
Research Report 87

Dr. Melikian and colleagues at the American Health Foundation developed and validated a novel, practical method for assaying metabolites of benzene in humans methods using a technique known as Liquid Chromatography–Electrospray Ionization–Tandem Mass Spectrometry (LC-ESI-MS/MS) to measure benzene metabolites in human urine.

Diesel Emissions and Lung Cancer: Epidemiology and Quantitative Risk Assessment

Health Effects Institute
June 1999
Special Report

A Special Report of the Institute's Diesel Epidemiology Expert Panel. Although epidemiologic data have been used generally to identify the hazards associated with exposure to diesel exhaust, questions remain as to whether the human data can be used to develop reliable estimates of the magnitude of any risk for lung cancer (that is, through quantitative risk assessment [QRA]), and whether new research efforts could provide any additional data needed. In response to such issues, the Health Effects Institute initiated the Diesel Epidemiology Project in 1998.

Statistical Methods for Epidemiologic Studies of the Health Effects of Air Pollution

William Navidi
Duncan Thomas
Bryan Langholz
Daniel Stram
May 1999
Research Report 86

Dr. Navidi and colleagues at the University of Southern California discussed the development of three sophisticated statistical methods that would improve the estimates of the health effects of air pollution obtained from epidemiologic studies. First, they took a standard case-crossover design and introduced a bidirectional element where control data were obtained both before and after the health event of interest.

Mechanisms of Response to Ozone Exposure: The Role of Mast Cells in Mice

Steven R Kleeberger
Malinda Longphre
Clarke G Tankersley
April 1999
Research Report 85

Dr. Kleeberger and colleagues at Johns Hopkins University compared ozone-induced inflammation, epithelial cell injury, and epithelial cell proliferation (a marker of cell injury) in three types of mice: mice with a normal content of mast cells, mutant mice without mast cells, and mutant mice whose mast cells were repleted by a bone marrow transplant from normal mice. Each group of mice was exposed to clean air or to ozone for varying lengths of time.

Evaluation of The Potential Health Effects of the Atmospheric Reaction Products of Polycyclic Aromatic Hydrocarbons

Andrew J Grosovsky
Jennifer C Sasaki
Janet Arey
David Eastmond
Karyn K Parks
Roger Atkinson
March 1999
Research Report 84

Dr. Arey and colleagues of the University of California, Riverside, examined the genotoxic potential of two PAHs (naphthalene and phenanthrene) that are common air pollutants, and a subset of their atmospheric transformation products. The investigators evaluated the genotoxicity of these compounds using a variety of human cell lines with a range of metabolic capabilities. They examined the ability of these compounds to produce small-scale (damage to genes) and large-scale (damage to chromosomes) genetic damage.

A Partnership to Examine Emerging Health Effects: EC/HEI Workshop on 1,3-Butadiene

Health Effects Institute
January 1998
Communication 6
Communication 6 contains proceedings from a workshop held in Brussels, Belgium, June 29–30 1998. Presentations focused on butadiene ambient concentrations, metabolism, mutagenicity, epidemiology, and a panel discussion on Butadiene Risk Assessment in the Regulatory Framework.

Daily Changes in Oxygen Saturation and Pulse Rate Associated with Particulate Air Pollution and Barometric Pressure

Douglas W. Dockery
C Arden Pope III
Richard E Kanner
G Martin Villegas
Joel Schwartz
January 1998
Research Report 83

Drs. Douglas Dockery at the Harvard School of Public Health and C. Arden Pope III at Brigham Young University speculated that exposure to PM might lead to a transient drop in blood oxygenation, which might have serious consequences in humans with heart or lung problems. The investigators designed a study to increase the possibility of observing PM effects by testing a potentially at-risk group (the elderly) at a time of year that historically had experienced relatively high levels of PM (the winter).