Publications

This page is a list of publications in reverse chronological order. Please use search or the filters to browse by research areas, publication types, and content types.

Displaying 271 - 280 of 293. Show 10 | 25 | 50 | 100 results per page.


Modulation of Pulmonary Defense Mechanisms Against Viral and Bacterial Infections by Acute Exposures to Nitrogen Dioxide

George J Jakab
November 1988
Research Report 20

This report investigated the influence of acute exposure to nitrogen dioxide on susceptibility to and severity of viral and bacterial infection in mice. Dr. Jakab exposed normal and immunosuppressed mice to concentrations of nitrogen dioxide ranging from 1 to 30 ppm before or after bacterial or viral challenge and measured host resistance to infection by physiologic parameters.

Potential Health Effects of Manganese in Emissions from Trap-Equipped Diesel Vehicles

Health Effects Institute
September 1988
Special Report

The use of ceramic particulate traps, in conjunction with manganese fuel additives, has been viewed as a way to reduce emissions of particulate matter from diesel-fueled vehicles. This Special Report focuses on the potential health effects from increased public exposure to manganese emissions from such use.

Factors Affecting Possible Carcinogenicity of Inhaled Nitropyrene Aerosols

Ronald K Wolff
Edward Barr
James A Bond
Arthur F Eidson
William C Griffith
Fletcher F Hahn
Jack R Harkema
Rogene F Henderson
Charles E Mitchell
Simon J Rothenberg
George M Shopp
James D Sun
August 1988
Research Report 19

This report assessed in rats the carcinogenicity of inhaled 1-nitropyrene, a compound frequently adsorbed to diesel particulate matter, and whether this effect is modified when 1-nitropyrene is associated with particles or irritant gases. Dr. Wolff and colleagues exposed rats to atmospheres containing 14C radiolabeled 1-nitropyrene alone or in combination with gallium oxide, sulfur dioxide, or both. After exposure, tissue samples were analyzed for radiolabel content to determine the tissue distribution of 1-nitropyrene and its metabolites.

Respiratory Infections in Coal Miners Exposed to Nitrogen Oxides

Michael Jacobsen
Tom A Smith
J Fintan Hurley
Alastair Robertson
Ralph Roscrow
July 1988
Research Report 18

This report investigated the association of occupational exposure to nitrogen oxides with respiratory infections in British coal miners. Dr. Jacobsen and colleagues leveraged data from the Pneumoconiosis Field Research Study, a long-term epidemiological study of British coal miners with information for the years 1953-1978.

Studies on the Metabolism and Biological Effects of Nitropyrene and Related Nitro-polycyclic Aromatic Compounds in Diploid Human Fibroblasts

Veronica M Maher
Joe Dale Patton
J Justin McCormick
March 1988
Research Report 17

This report describes a study by Dr. Maher and colleagues to investigate the biological effects of nitropyrene compounds, found in diesel emission particulate, on diploid human fibroblasts in culture in order to better evaluate potential health effects. Diploid human fibroblasts from normal individuals and individuals with a genetic predisposition to cancer were studied and compared through a series of experiments.

Metabolism and Biological Effects of Nitropyrene and Related Compounds

Charles M King
February 1988
Research Report 16

This report describes a study by Dr. King to investigate in rats the carcinogenetic properties of nitropyrene and related compounds and how these compounds are metabolically activated in target tissues. Nitropyrenes and related nitroaromatics are of interest because of their ubiquity in diesel emissions and reported carcinogenicity.

Susceptibility to Virus Infection with Exposure to Nitrogen Dioxide

Thomas J Kulle
Mary Lou Clements
January 1987
Research Report 15

This report addressed the hypothesis that exposure to oxidant air pollutants enhances susceptibility to viral infection. Drs. Kulle and Clements exposed healthy human volunteers who were seronegative to cold-adapted influenza A virus to clean air or nitrogen dioxide concentrations of 1, 2, or 3 ppm for two hours a day for three consecutive days. Live influenza A virus was administered intranasally to all participants after the second day of exposure.

The Effects of Ozone and Nitrogen Dioxide on Lung Function in Healthy and Asthmatic Adolescents

Jane Koenig
William E Pierson
Susan Gayle Marshall
David S Covert
Michael S Morgan
Gerald van Belle
January 1987
Research Report 14

This report investigated whether asthmatic and healthy adolescents differ in their sensitivity to near-ambient concentrations of ozone and nitrogen dioxide. Dr. Koenig and colleagues exposed healthy and asthmatic participants to concentrations of 0.12 and 0.18 ppm ozone or 0.12 and 0.18 ppm nitrogen dioxide during rest or rest followed by moderate exercise.

Effects of Nitrogen Dioxide on Alveolar Epithelial Barrier Properties

Edward D Crandall
Jeffrey M Cheek
Marian E Shaw
Edward M Postlethwait
October 1987
Research Report 13

This report describes a study by Dr. Crandall and colleagues to investigate the ability of nitrogen dioxide (NO2) to adversely alter the barrier and transport properties of mammalian alveolar epithelium and cause pulmonary edema. Rat type II alveolar cell monolayers cultured on non-porous and porous surfaces were used as models of isolated alveolar epithelium for in vitro exposure to NO2.

Neurotoxicity of Prenatal Carbon Monoxide Exposure

Laurence D Fechter
September 1987
Research Report 12

This report describes a study by Dr. Fechter to investigate the effect of prenatal and neonatal exposure to low levels of carbon monoxide (CO) on the developing rat brain. Groups of rats were exposed prenatally, or prenatally plus 10 days neonatally to take into account the fact that the developing rat brain is considerably less mature at birth than the primate brain. Consequently, rats were exposed to CO concentrations ranging from 75-300 ppm through the period of neuronal proliferation and into the period of synapse formation.