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Gasoline Vapor Exposure and Human Cancer: Evaluation of Existing Scientific Information and Recommendations for Future Research

Health Effects Institute
September 1985
Special Report

Report of the Institute's Health Review Comittee, September 1985. Supplement, January 1988. This report contains a review of data on the health effects of unburnt gasoline vapors, and evaluates the need for a research program to address major unresolved issues, especially in regard to the carcinogenicity of gasoline vapors. The supplement summarizes additional data published between 1985 and 1988 in response to a proposed regulatory strategy to reduce hydrocarbon emissions from mobile sources.

Estimation of Risk of Glucose 6-Phosphate Dehydrogenase Deficient Red Cells to Ozone and Nitrogen Dioxide

Marie A Amoruso
August 1985
Research Report 1

Acute hemolytic anemia is associated with a deficiency in glucose 6-phosphate dehydrogenase (G6PD), an X-linked inheritable characteristic. Hemolytic anemia is thought to be caused by a depletion of glutathione and other reducing compounds in red blood cells. Dr. Amoruso and colleagues sought to experimentally test the Calabrese hypothesis, which suggests that G6PD-deficient individuals may be at an increased risk of hemolysis during exposure to low levels of oxidants such as ozone.