Publications

This page is a list of publications in reverse chronological order. Please use search or the filters to browse by research areas, publication types, and content types.

Displaying 181 - 190 of 317. Show 10 | 25 | 50 | 100 results per page.


Respiratory Epithelial Penetration and Clearance of Particle-Borne Benzo[a]pyrene

Per Gerde
Bruce A Muggenburg
Margot Lundborg
Yohannes Tesfaigzi
Alan R Dahl
April 2001
Research Report 101

Dr. Gerde and colleagues at the Lovelace Respiratory Research Institute examined the effects of organic compounds in diesel exhaust such as genotoxic polynuclear aromatic compounds (PAHs). The investigators removed most of the organic compounds from diesel exhaust particles and bound radioactive Benzo[a]pyrene (BaP), a type of PAH is known to cause cancer in laboratory animals, to them. They exposed the lower respiratory tract of three dogs to the particles and measured the levels of particle-bound BaP and free BaP released from particles in the peripheral region of the lungs.

Respiratory Tract Toxicity in Rats Exposed to Mexico City Air

Owen R Moss
Elizabeth A Gross
R Arden James
Derek B Janszen
Paul W Ross
Kay C Roberts
Andrew M Howard
Jack R Harkema
Lilian Calderon-Garciduenas
Kevin T Morgan
March 2001
Research Report 100

Dr. Moss of CIIT evaluated the effects of rats exposed to ambient air in a highly polluted area in southwestern Mexico City. Pathologists have found evidence of cell damage and inflammation in nasal tissue from some human residents of this highly polluted area that was not present in people living in areas of the country with cleaner air and this study sought to determine if those effects could be replicated in rats.

A Case-Crossover Analysis of Fine Particulate Matter Air Pollution and Out-of-Hospital Sudden Cardiac Arrest

Harvey Checkoway
Drew Levy
Lianne Sheppard
Joel D Kaufman
Jane Koenig
David Siscovick
December 2000
Research Report 99

Dr Checkoway and colleagues at the University of Washington tested the primary hypothesis that increases in daily fine particle levels were related to increased risk of out-of-hospital sudden cardiac arrest. Sudden cardiac arrest and questionnaire data, and exposure data were obtained from the Puget Sound Clean Air Agency (Seattle WA). The investigators used a case-crossover study design; for each case of sudden cardiac arrest, a time period when the person was disease free was selected as a matched "referent" period.

Health Implications of Technological Responses to Climate Change

The Heinz Center
Health Effects Institute
November 2000
Workshop Report

Report of a workshop held November 29-30, 2000, sponsored by The H. John Heinz III Center for Science, Economics and the Environment, and the Health Effects Institute. 

Daily Mortality and Fine and Ultrafine Particles in Erfurt, Germany. Part I: Role of Particle Number and Particle Mass

H-Erich Wichmann
Claudia Spix
Thomas Tuch
Gabriele Wölke
Annette Peters
Joachim Heinrich
Wolfgang Kreyling
Joachim Heyder
November 2000
Research Report 98

Dr H-Erich Wichmann and colleagues at the National Research Center for Environment and Health in Germany prospectively studied the association of daily mortality data with the number and mass concentrations of ultrafine and fine particles in Erfurt, Germany. Concentrations were measured near a road and a time-series approach was used to look at short-term changes in particle concentration and concurrent deaths due to cardiovascular and respiratory causes over a period of 3.5 years.

Identifying Subgroups of the General Population That May Be Susceptible to Short-Term Increases in Particulate Air Pollution: A Time-Series Study in Montreal, Quebec

Mark S Goldberg
John C Bailar III
Richard T Burnett
Jeffrey R Brook
Robyn Tamblyn
Yvette Bonvalot
Pierre Ernst
Kenneth M Flegel
Ravinder K Singh
Marie-France Valois
October 2000
Research Report 97

Dr. Mark Goldberg and his colleagues at McGill University conducted a time-series study in Montreal using available data from the Quebec Health Insurance Plan and mortality and air pollution data to better the understanding of the mortality-particulate association. Because of the comprehensive nature of this health insurance database, the investigators were able to link individual deaths in Montreal to medical information up to 5 years before death.

Association of Particulate Matter Components with Daily Mortality and Morbidity in Urban Populations

Morton Lippmann
Kazuhiko Ito
Arthur Nádas
Richard T Burnett
August 2000
Research Report 95

Dr Morton Lippmann and colleagues at the New York University School of Medicine attempted to identify and characterize components of PM and other air pollution mixtures that were associated with excess daily deaths and elderly hospital admissions in and around the area of Detroit, Michigan. Using publicly available data from 1985-1990 and 1992-1994, the investigators used statistical models to weigh the strength of one pollutant or two pollutants concurrently.

Reanalysis of the Harvard Six Cities Study and the American Cancer Society Study of Particulate Air Pollution and Mortality

Health Effects Institute
July 2000
Special Report

A Special Report of the Institute's Particle Epidemiology Reanalysis Project. The overall objective of this project was to conduct a rigorous and independent assessment of the findings of the Harvard Six Cities and American Cancer Society Studies of air pollution and mortality. This objective was met in two parts. In Part I: Replication and Validation, the Reanalysis Team led by Dr. Daniel Krewski sought to replicate the original studies via a quality assurance audit of a sample of the original data and to validate the original numeric results.

National Morbidity, Mortality, and Air Pollution Study. Part II: Morbidity and Mortality from Air Pollution in the United States

Jonathan M Samet
Scott L Zeger
Francesca Dominici
Frank Curriero
Ivan Coursac
Douglas W. Dockery
Joel Schwartz
Antonella Zanobetti
June 2000
Research Report 94-II

The National Morbidity, Mortality, and Air Pollution Study (NMMAPS) was designed to select multiple locations based on the specific criteria of population size and availability of PM10 data from the US Environmental Protection Agency's Aerometric Information Retrieval System (AIRS) database, and to apply the same statistical procedures to all locations. Dr Jonathan Samet and his colleagues Johns Hopkins University conducted a time-series study of mortality effects in large US cities representing various levels of PM10 and gaseous pollutants.

National Morbidity, Mortality, and Air Pollution Study. Part I: Methods and Methodologic Issues

Jonathan M Samet
Francesca Dominici
Scott L Zeger
Joel Schwartz
Douglas W. Dockery
June 2000
Research Report 94-I

In an effort to address the uncertainties regarding the association between PM and daily mortality, and to determine the effects of other pollutants on this association, HEI funded the National Morbidity, Mortality, and Air Pollution Study (NMMAPS). Dr Jonathan Samet and his colleagues at Johns Hopkins University, in collaboration with investigators at Harvard University, conducted this time-series study in large cities across the US where levels of PM and gaseous pollutants were varied.