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HEI’s interest and commitment to accountability or health outcomes studies stems in large measure from the importance of assessing whether potentially costly and complex regulations and other interventions are yielding the demonstrable improvements in air quality pollution and public health that were initially projected. In addition, lessons learned about regulatory efficacy from these studies are a means of informing the design and implementation of future efforts to improve air quality. HEI defined initial concepts and methods with the publication of a major Monograph (HEI Communication 11, 2003). Subsequently, HEI funded two waves of research and will be planning a third wave in the coming years.