Health Effects Institute Annual Conference 2021

Chairs: Francesca Dominici, Harvard T.H. Chan School of Public Health, HEI Research Committee, and Peter Thorne, University of Iowa, HEI–Energy Research Committee

Investigating and addressing environmental health research questions requires collaboration among researchers, affected communities, policymakers, and other stakeholders before, during, and after research is conducted. Engaging communities facing socioeconomic or racial inequities throughout the research process can be challenging, despite the public health importance of doing so. In this session, we will hear case studies of environmental health research that both informs and is informed by the affected communities. These will be followed by a panel discussion on ethical considerations in working with communities as well as the benefits and challenges that come with community involvement.

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Chairs: Eloise Marais, University College London, HEI Global Health Oversight Committee, and Jana Milford, University of Colorado, HEI Review Committee

Health impact assessments conducted around the globe point to the substantial burden of disease attributed to air pollution. Yet for a variety of reasons, both scientific and political, progress has stalled in addressing air pollution in many regions of the world. An increasing number of analytical approaches are emerging at global to local scales to help characterize air pollution sources, the relative health benefits of reducing them, and the cost-effectiveness of different approaches. Using results from a new global study on source-specific impacts of air pollution (Global Burden of Disease–Major Air Pollution Sources) as an example, this session will provide an overview of key approaches and discuss their implications for informing policies and solutions with a view to improve air quality at national and local scales.

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Chairs: Jeff Brook, University of Toronto, HEI Research Committee, and Barbara Hoffmann, University of Düsseldorf, HEI Research Committee

The COVID-19 pandemic has led to widespread disruptions of society, including closures of businesses, schools, and industrial activities, and there have been unprecedented restrictions on travel at all scales. All of this has led to reductions in emissions of air pollution and changes in air quality in locations around the world. Relatedly, there is emerging evidence that exposure to air pollution may be associated with increased susceptibility to infection from COVID-19, with increased adverse symptoms and duration of the disease, as well as increased risk of mortality. This session will discuss these potential linkages, along with evidence of racial inequalities in exposures to air pollution and in COVID-19 outcomes, and discuss challenges in studying these issues. Lastly, the session will bring in the "One Health" approach, recognizing the interconnections between people, animals, and plants and their shared environment.

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Chairs: Neil Pearce, London School of Hygiene and Tropical Medicine, HEI Research Committee, and Jennifer Peel, Colorado State University, HEI Review Committee

Synthesizing evidence relevant to public health is now more important than ever. Evidence synthesis may include systematic reviews or formal meta-analyses of the findings of observational studies. There have been evolving approaches to synthesis and integration of various forms of evidence throughout the years, for example, the weight of evidence’s approach that the US EPA use in their integrated science assessments. Another approach is Grading of Recommendations Assessment, Development and Evaluation (GRADE), which has its origins in clinical research and has been adopted by the WHO and Cochrane Collaboration. It has been applied recently to assess the quality of evidence for environmental exposures, such as air pollution. However, GRADE considers results from randomized studies as higher-quality evidence than non-randomized designs, a criterion that creates difficulties in environmental research, where randomized designs are largely not possible, thus down-grading important evidence by default. Alternative promising strategies for evidence synthesis have been suggested, including "triangulation". This session will examine approaches for evidence synthesis in environmental epidemiology and discuss possible paths forward.

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Chairs: Michael Jerrett, University of California, Los Angeles, HEI Review Committee, and Allen Robinson, Carnegie Mellon University, HEI Research Committee

With recent and ongoing substantial reductions in tailpipe emissions, there is increasing interest in non-tailpipe emissions, particularly in particles from tire and brake wear and road dust, and their potential health effects. This session will discuss the state of knowledge on non-tailpipe contributions to ambient concentrations and exposures to particulate matter, bringing in several disciplinary approaches, including measurement, modeling, toxicology, and epidemiology. The session will discuss both current conditions and likely future scenarios given expected changes in vehicle fleets as well as developments in brake and tire technology.

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This session is an opportunity to meet the new generation of researchers and learn about their research directions in the field of air pollution and health. Speakers at the session are winners of the Jane Warren Trainee Conference Award 2021. The award is presented in remembrance of Dr. Jane Warren who joined HEI in the 1980s and served as the Director of Science from 1999 until her retirement in 2008; it is awarded to graduate students or postdoctoral scholars at academic or research institutions.

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Chairs: Amy Herring, Duke University, HEI Research Committee, and Sverre Vedal, University of Washington

In 2015, HEI funded three studies to investigate the health effects of long-term exposures to low levels of air pollution in very large populations across the United States, Canada, and Europe. This session will present results from these recently completed studies, discuss their strengths and weaknesses, and discuss potential implications for future risk assessment and regulation.  Highlights include thorough examinations of concentration–response functions, results for multiple health endpoints (e.g., cause-specific mortality, respiratory events), as well as multiple pollutants (e.g., PM_2.5, O₃, NO₂), and causal modeling approaches.

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