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Making the MOSES data and specimens available

May 2018

HEI is making available to the public the database and material of the Multicenter Ozone Study in oldEr Subjects (MOSES). In the interest of scientific transparency and to encourage the broadest possible use of the data and the material, HEI has set up a streamlined process to access the data and the material (subject to the limited quantities available). Please see the Data and Material Sharing Plans below. 

The MOSES database resides on the Harvard Dataverse public repository and may be accessed by anyone who is interested, without restrictions starting on May 15, 2018. Access to the database requires an initial log-in step that includes a brief questionnaire and terms and conditions for publications resulting from the research. Subsequent access to the supporting documentation (including the programming guide), to excel files, and to the MOSES final report does not require logging in. The database resides at https://dataverse.harvard.edu/dataverse/MOSES.

The MOSES material consists of blood and plasma samples for all 87 subjects. These are stored at a commercial repository. A small number of sputum samples is stored at the MOSES Sputum Core Lab at the University of North Carolina at Chapel Hill and is also made available. Any qualified researcher from a not-for-profit US research center interested in doing specific analyses can request the samples.

HEI has delegated the Original Investigators to be custodians of the material and make decisions on their distribution and use, and to keep HEI informed of all requests and disposition of the material. Interested researchers should submit a short Material Request Form to the MOSES Original Investigators and sign a Material Transfer Agreement (see documents below). The Request Form should include: (1) the types of materials requested and explanation of their intended use; (2) the rationale and aim of the research project; (3) a description of what the research project will add to scientific knowledge; (4) the experimental methods; (5) the estimated duration of the research; and (6) a short curriculum vitae of the recipient (maximum 2 pages). Requests for material will be reviewed starting on July 1, 2018. 

For questions, please contact Maria Costantini or Annemoon van Erp.