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10-3 Health Effects of Air Pollution

Status: 
Not Active
Number: 
RFPA 10-3

RFPA 10-3 provides a mechanism for investigators whose area of interest falls outside of the current RFAs but is compatible with the HEI research program and mission. Fall 2010 RFA booklet

How to Apply

This RFA is closed.

Ongoing studies funded under this RFA

Duke University

This study will be examining the effect of exposure to air pollution on biomarkers of cardiovascular metabolic risk and blood-borne whole genome gene expression profiles in a cohort with clinically evident heart disease.

Status: 
In review
.  Read more...

Publications from this RFA

Research Report 186
David Q. Rich
Annette Peters
Alexandra Schneider
Wojciech Zareba
Susanne Breitner
David Oakes
Jelani Wiltshire
Cathleen Kane
Mark W Frampton
Regina Hampel
Philip K Hopke
Josef Cyrys
Mark J Utell
May 2016

Using data from four previously completed studies (two panel studies and two controlled-exposure studies), David Rich and Annette Peters and their teams investigated potential mechanisms behind the effects of short-term exposure to PM2.5 and ultrafine particles on changes in cardiac rhythm, including heart rate variability and other ECG parameters.

Research Report 191
Allison D Fryer
David B Jacoby
Sarah A Wicher
March 2017

Research Report 191 describes a study by Allison Fryer and colleagues that addressed how exposure to ozone affects the immune and physiological responses in guinea pigs. In her study, Dr. Fryer focused on eosinophils, white blood cells that play an important role in inflammation, allergies, and allergic asthma, and can modify the airway response to ozone inhalation. This study tested a novel hypothesis: that allergic guinea pigs react differently to ozone than normal animals because of newly formed eosinophils that migrate from bone marrow to the lungs.