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10-1 Cardiovascular Effects of Exposure to Low Levels of Ozone in the Presence or Absence of Other Ambient Pollutants

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RFA 10-1

Two types of studies are sought to evaluate cardiovascular and respiratory effects in healthy human volunteers, aged 55 and above. In Phase 1, volunteers will be exposed to ozone alone, at concentrations between 60 and 100 ppb, in a controlled laboratory setting. In Phase 2, volunteers will be exposed to real-world ambient air pollution at sites with ozone concentrations comparable to those used in Phase 1. Interested scientists may apply for Phase 1, Phase 2, or both.
Winter 2010 RFA booklet

How to Apply

This RFA is closed.

Ongoing studies funded under this RFA

University of North Carolina–Chapel Hill

University of Rochester

This multi-center study focused on the effects of ozone in human volunteers, aged 55 to 70 years, who were exposed in chambers to near ambient levels of ozone with intermittent exercise. Effects on the cardiovascular system, along with changes in pulmonary function, inflammation and oxidative stress were studied. Part 1 has been published (see link below). Part 2 of the study is ongoing, to further analyze the participant's prior exposures to ambient air pollutants and conduct additional analyses of the rich dataset.  

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Publications from this RFA

Research Report 192 Part 1
Mark W Frampton
John R Balmes
Philip A Bromberg
Paul Stark
Mehrdad Arjomandi
Milan J Hazucha
David Q Rich
Danielle Hollenbeck-Pringle
Nicholas Dagincourt
Neil Alexis
Peter Ganz
Wojciech Zareba
Maria G Costantini
June 2017

HEI Research Report 192 describes a multicenter study by John Balmes at the University of California–San Francisco, Phil Bromberg at the University of North Carolina–Chapel Hill, and Mark Frampton at the University of Rochester, New York. The study was designed to test whether ozone has short-term cardiovascular effects at present-day ambient levels. It evaluated respiratory and cardiovascular outcomes in 87 healthy participants (60 years old on average) who were exposed to 0, 70, or 120 ppb ozone for 3 hours while exercising moderately.