Publications

This page is a list of publications in reverse chronological order. Please use search or the filters to browse by research areas, publication types, and content types.

Displaying 81 - 90 of 288. Show 10 | 25 | 50 | 100 results per page.


Outdoor Air Pollution and Health in the Developing Countries of Asia: A Comprehensive Review

Health Effects Institute
November 2010
Special Report 18

This comprehensive literature review to come out of HEI's Public Health and Air Pollution in Asia (PAPA) program builds on an initial assessment conducted in 2004 and describes the current scope of the Asian literature on the health effects of outdoor air pollution, enumerating and classifying more than 400 studies. In addition, the report includes a systematic and quantitative assessment of 82 time-series studies of daily mortality and hospital admissions for cardiovascular and respiratory disease.

Public Health and Air Pollution in Asia (PAPA): Coordinated Studies of Short-Term Exposure to Air Pollution and Daily Mortality in Four Cities

Haidong Kan
et al.
Zhengmin Qian
et al.
Nuntavarn Vichit-Vadakan
et al.
Chit-Ming Wong
et al.
November 2010
Research Report 154

This report describes the first set of coordinated time-series studies ever undertaken in Asian cities: four time-series studies of the health effects of air pollution in Bangkok, Hong Kong, Shanghai, and Wuhan. These studies were intended to help bridge the gaps between studies conducted in different locations around the globe.

Pulmonary Effects of Inhaled Diesel Exhaust in Young and Old Mice: A Pilot Project

Debra L Laskin
Gediminas Mainelis
Barbara J Turpin
Kinal J Patel
Vasanthi R Sunil
September 2010
Research Report 151

This report explores the possible physiological basis for epidemiologic results suggesting that people over the age of 55 are more sensitive than younger people to the effects of exposure to particulate matter. Dr. Debra Laskin and colleagues hypothesized that this sensitivity resulted from the lung cells of the elderly producing less of the cytokine tumor necrosis factor-α (a cell protein involved in systemic inflammation), as compared with the lung cells of the young after exposure to air pollution.

Proceedings of an HEI Workshop on Further Research to Assess the Health Impacts of Actions Taken to Improve Air Quality

Health Effects Institute
August 2010
Communication 15

Communication 15, Proceedings of an HEI Workshop on Further Research to Assess the Health Impacts of Actions Taken to Improve Air Quality, summarizes the findings of a workshop held in December 2009 that reviewed the current state of research to evaluate the impact of air quality interventions (also known as accountability or air quality outcomes research).

Mutagenicity of Stereochemical Configurations of 1,3-Butadiene Epoxy Metabolites in Human Cells

Ryan Q Meng
Linda C Hackfeld
Richard P Hodge
Lynne A Wisse
Diana L Redetzke
Vernon E Walker
June 2010
Research Report 150

This report describes a study by Dr. Ryan Meng and colleagues to determine the role of stereochemistry in the cytotoxicity and mutagenicity of three major butadiene metabolites. This study is a part of HEI's program of research in air toxics; one important aim of that program has been to fill key gaps in risk assessment for some of the most important chemicals. Butadiene is present in motor vehicle exhaust and other emissions and is listed by the U.S.

Development and Application of a Sensitive Method to Determine Concentrations of Acrolein and Other Carbonyls in Ambient Air

Thomas M Cahill
M Judith Charles
Vincent Y Seaman
May 2010
Research Report 149

This report describes a study by Dr. Thomas Cahill and colleagues to create and evaluate a new method to measure acrolein and other volatile carbonyls present at low concentrations in ambient air. Acrolein is an important aldehyde that is very difficult to measure accurately, so developing better methods for measuring levels and exposure is critical to better risk assessment for the chemical. The investigators developed a sampler that traps acrolein using sodium bisulfite in an aqueous medium.

Atmospheric Transformation of Diesel Emissions

Barbara Zielinska
Shar Samy
Jacob D McDonald
JeanClare Seagrave
April 2010
Research Report 147

This report describes a study by Dr. Barbara Zielinska and colleagues to investigate the changes that fresh diesel emissions undergo when they are mixed with ambient air, due to reactions with sunlight and other pollutants. The investigators also evaluated how those changes may affect the toxic properties of diesel emissions. The study used a relatively new (2003 model) light duty diesel engine (although not one with a diesel filter) and provides insight into the complexity of diesel exhaust composition in the real world.

Impact of Improved Air Quality During the 1996 Summer Olympic Games in Atlanta on Multiple Cardiovascular and Respiratory Outcomes

Jennifer L Peel
Mitchell Klein
W Dana Flanders
James A Mulholland
Paige E Tolbert
April 2010
Research Report 148

This report is the latest in HEI's program of studies to assess the health impacts of air quality actions. Research Report 148 describes a study to evaluate the effect of a short-term, temporary intervention to reduce traffic congestion during the 1996 Summer Olympic Games in Atlanta, Georgia. A previous study had shown a decrease in acute care visits for pediatric asthma and a concomitant decrease in concentrations of ozone, particulate matter, and carbon monoxide.

Traffic-Related Air Pollution: A Critical Review of the Literature on Emissions, Exposure, and Health Effects

Health Effects Institute
January 2010
Special Report 17

A Special Report of the Institute's Panel on the Health Effects of Traffic-Related Air Pollution. This report is the most comprehensive and systematic review to date of the scientific literature on emissions, exposure, and health effects from traffic-related air pollution. It includes conclusions about the populations exposed around major roads, the associations between exposure to air pollution from traffic and human health, and important remaining data gaps. Compared with the initial pre-print version released in May 2009, this final version has undergone data verification and editorial changes; however, the overall conclusions did not change.

The Role of T Cells in the Regulation of Acrolein-Induced Pulmonary Inflammation and Epithelial-Cell Pathology

Michael T Borchers
Scott C Wesselkamper
Hitesh Deshmukh
Erin Beckman
Mario Medvedovic
Maureen Sartor
George D Leikauf
December 2009
Research Report 146

This report describes a study to investigate the role of two subpopulations of T cells in the airway response to inhaled acrolein, a toxic pollutant in ambient air, which US EPA's National Air Toxics Assessment has identified as having broad effects. Dr. Michael Borchers and colleagues measured inflammation and injury in response to acrolein in the lungs of mice that are genetically deficient in the specific T-cell subpopulations. He also measured changes in gene expression in the T-cell subpopulations after acrolein exposure. This study was funded under the Walter A.