This page is a list of publications in reverse chronological order. Please use search or the filters to browse by research areas, publication types, and content types.

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DNA Adducts of Nitropyrene Detected by Specific Antibodies

John D Groopman
April 1987
Research Report 7

Research Report 7 describes a study that attempted to produce monoclonal antibodies to DNA adducts of nitropyrene that could be used to study the mechanism of nitropyrene-induced carcinogenesis or develop analytical techniques for monitoring exposed populations. Dr. Groopman immunized mice against nitropolycyclic aromatic hydrocarbons conjugated with a carrier protein to study the progression of immune response. Dr. Groopman injected four antigens into groups of BALB/c, AJ, and NZB mice. Two of the antigens failed to produce any immune response.

Effect of Nitrogen Dioxide, Ozone, and Peroxyacetyl Nitrate on Metabolic and Pulmonary Function

Deborah M Drechsler-Parks
April 1987
Research Report 6

Dr. Drechsler-Parks and colleagues at the Institute of Environmental Stress sought to examine the effects of nitrogen dioxide, ozone, and peroxyacetyl nitrate on metabolic and pulmonary function. Because it is possible that two or more pollutants could interact in ambient air and cause effects that could not be predicted from the effects observed with the individual pollutants, the investigators examined varying levels of different pollutants in 32 non-smoking men and women (8 men and 8 women 18-26 years of age and 8 men and 8 women 51-76 years of age).

An Investigation into the Effect of a Ceramic Particle Trap on the Chemical Mutagens in Diesel Exhaust

Susan T Bagley
Linda D Dorie
David G Leddy
John H Johnson
January 1987
Research Report 5

Dr. Bagley and colleagues at Michigan Technical University examined the chemical mutagenic effects of a ceramic particle trap on a medium-duty diesel engine. Diesel exhaust particles and vapor phase samples were collected from diluted (15:1) exhaust of a 10.4L displacement Caterpillar 3208 engine. The investigators compared uncontrolled (baseline) emissions with exhaust that had been modified by the use of an uncatalyzed monolithic ceramic trap.

The Metabolic Activation and DNA Adducts of Dinitropyrenes

Frederick A Beland
August 1986
Research Report 4

Nitrated polycyclic aromatic hydrocarbons (PAHs) are common environmental contaminants that often contain genotoxic activity. Dinitropyrenes are a class of PAHs that are associated with diesel exhaust. In this study, Dr. Beland and colleagues at the University of Arkansas for Medical Sciences sought to determine what factors contribute to the extreme genotoxicity of dinitropyrenes in bacteria and to establish if the same factors were important for the genotoxicity of dinitropyrenes in mammalian systems.

Transport of Macromolecules and Particles at Target Sites for Deposition of Air Pollutants

TT Crocker
DK Bhalla
February 1986
Research Report 3

The pulmonary epithelium is a cellular, avascular layer of tissue that is the first point of contact between the lung and inhaled pollutants. Previous research has indicated that altered epithelial permeability may be an early marker of subsequent lung damage. Dr. Crocker and colleagues at the University of California, Irvine sought to study the study the sites of epithelial injury in rat airways following inhalation of formaldehyde, ozone, and nitrogen dioxide.

Disposition and Metabolism of Free and Particle-Associated Nitropyrenes After Inhalation

James A Bond
Michele A Medinsky
James D Sun
January 1986
Research Report 2

Nitro-polynuclear aromatic hydrocarbons, including 1-nitropyrene, are constituents of diesel exhaust. Previous fractionation research has suggested that 1-nitropyrene and various dinitropyrenes may account for 20-50% of the total mutagenicity in the diesel particle extract (DPE). Dr. Bond and colleagues at the Inhalation Toxicology Research Institute examined the biological fate of inhaled 14C-1-nitropyrene (NP) in Fischer-344 rats.

Gasoline Vapor Exposure and Human Cancer: Evaluation of Existing Scientific Information and Recommendations for Future Research

Health Effects Institute
September 1985
Special Report

Report of the Institute's Health Review Comittee, September 1985. Supplement, January 1988. This report contains a review of data on the health effects of unburnt gasoline vapors, and evaluates the need for a research program to address major unresolved issues, especially in regard to the carcinogenicity of gasoline vapors. The supplement summarizes additional data published between 1985 and 1988 in response to a proposed regulatory strategy to reduce hydrocarbon emissions from mobile sources.

Estimation of Risk of Glucose 6-Phosphate Dehydrogenase Deficient Red Cells to Ozone and Nitrogen Dioxide

Marie A Amoruso
August 1985
Research Report 1

Acute hemolytic anemia is associated with a deficiency in glucose 6-phosphate dehydrogenase (G6PD), an X-linked inheritable characteristic. Hemolytic anemia is thought to be caused by a depletion of glutathione and other reducing compounds in red blood cells. Dr. Amoruso and colleagues sought to experimentally test the Calabrese hypothesis, which suggests that G6PD-deficient individuals may be at an increased risk of hemolysis during exposure to low levels of oxidants such as ozone.