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August 2016

专题报告20,燃煤和其他主要大气污染源所致的中国疾病负担。报告从国家与省级层面,对中国燃煤及其他主要空气污染源释放的细颗粒物(PM2.5)所造成当前及未来疾病负担进行了第一次综合评估。此项报告由清华大学、健康影响研究所、健康指标和评估研究所(IHME)与不列颠哥伦比亚大学联合发布,是全球疾病负担-主要空气污染源(GDB MAPS)这一国际合作项目的研究结果。分析表明,燃煤是造成空气污染、影响健康的最大元凶。2013年,仅燃煤一项在中国就导致约36.6万人过早死亡,其中以工业与民用燃煤影响最为重大。报告还指出,如不采取进一步行动,到2030年健康负担将会大幅增加。Burden of Disease Attributable to Coal-Burning and Other Air Pollution Sources in China (in English)

Adverse Reproductive Health Outcomes and Exposure to Gaseous and Particulate-Matter Air Pollution in Pregnant Women

Jun Wu
Olivier Laurent
Lianfa Li
Jianlin Hu
Michael Kleeman
July 2016
Research Report 188

HEI Research Report 188 analyzes associations between increases in various air pollution exposure metrics and increased risks of preterm birth. Jun Wu was funded under HEI's Walter A. Rosenblith New Investigator Award to conduct a comprehensive nested, case-control study of air pollution and adverse birth and pregnancy outcomes, using birth certificate data collected in California from 2001 to 2008. 

Update Summer 2016

Health Effects Institute
July 2016

This edition of Update reports on HEI's presentation of GBD MAPS results at a major Chinese air pollution meeting; HEI's Annual Conference in Denver in May; two new HEI research reports on the effects of air pollution on birth and pregnancy outcomes; a meeting of the National Association of Clean Air Agencies at which HEI shared research results with diverse experts and regulators; and HEI's participation at a EPA Clean Air Act Advisory Committee meeting in June.

New Methods to Detect Aerosol Chemical Composition-Induced Reactive Oxygen Species in a Biological Model

Richard E Peltier
Whitney Huynh
Pallavi Pant
Massimiliano Mascelloni
June 2016
Unpublished report

This unpublished research report describes a two-year study aimed at building and testing a method for the semi-continuous measurement of reactive oxidant species (ROS) generated by particulate matter in a cellular assay. The assay relied on the use of a compound that turns into a fluorescent product upon reaction with ROS generated in the cells.

Causal Inference Methods for Estimating Long-Term Health Effects of Air Quality Regulations

Corwin M. Zigler
Chanmin Kim
Christine Choirat
John Barrett Hansen
Yun Wang
Lauren Hund
Jonathan Samet
Gary King
Francesca Dominici
May 2016
Research Report 187

HEI Research Report 187 was funded as part of HEI’s Accountability research program, aimed at understanding whether actions to improve air quality have resulted in improved health outcomes. Corwin M. Zigler and his colleagues used existing and newly developed statistical methods to assess whether an intervention was causally related to changes in pollutant levels or health outcomes, and applied their methods in two well-developed case studies: effects of air quality interventions to reduce PM10 concentrations in nonattainment areas and the impact of installation of scrubber technologies on emissions from coal-fired power plants.

Ambient and Controlled Particle Exposures as Triggers for Acute ECG Changes

David Q. Rich
Annette Peters
Alexandra Schneider
Wojciech Zareba
Susanne Breitner
David Oakes
Jelani Wiltshire
Cathleen Kane
Mark W Frampton
Regina Hampel
Philip K Hopke
Josef Cyrys
Mark J Utell
May 2016
Research Report 186

Using data from four previously completed studies (two panel studies and two controlled-exposure studies), David Rich and Annette Peters and their teams investigated potential mechanisms behind the effects of short-term exposure to PM2.5 and ultrafine particles on changes in cardiac rhythm, including heart rate variability and other ECG parameters.

Update Spring 2016

Health Effects Institute
May 2016

This newsletter reports on a third study under way in Europe to complete the comprehensive HEI effort to examine the potential health effects of air pollution at low levels; HEI's new research program focusing on the health effects of exposure to traffic-related pollution; and the GBD MAPS team's presentation of preliminary data on coal’s impact on health in China. In addition, it covers the publication of two new research reports covering novel statistical methods for studying pollutant mixtures and a “direct” approach evaluating the impact of air quality interventions through “causal inference” methods, as well as the retirement of HEI's Aaron Cohen, a strategy session held with HEI's sponsors, and HEI in the news.

Modeling of Multipollutant Profiles and Spatially Varying Health Effects with Applications to Indicators of Adverse Birth Outcomes

John Molitor
Eric Coker
Michael Jerrett
Beate Ritz
Arthur Li
April 2016
Research Report 183, Part III

This report is Part 3 of HEI Research Report 183, Development of Statistical Methods for Multipollutant Research. It describes a study to develop and apply statistical methods to analyze the effects of multipollutant exposures on health, expanding beyond the two-pollutant approaches used in many studies to date. HEI funded three innovative studies in recent years to improve the tools for analyzing complex multipollutant exposures. In this last report from these studies, John Molitor and colleagues describe a Bayesian framework to identify spatial clusters of air pollution exposures — and other covariates such as socioeconomic status — and estimated pregnancy outcomes associated with those clusters, using a data set for Los Angeles county. 

Update Winter 2016

Health Effects Institute
February 2016

The Winter Update newsletter features the upcoming HEI Annual Conference (sign up now!), a new member of the Review Committee, and a Global Burden of Disease Workshop in Mumbai, India, to calculate air pollution’s impact on global health. Also read about HEI’s study of changes in emissions in tunnels with the advent of new technology and HEI’s pending move to a new home.

Annual Report

Health Effects Institute
January 2016
Annual Report

The 2015 Annual Report – Vision 2020 - describes HEI’s partnership with scientists, government, industry, and the environmental community to provide high-quality, impartial, and relevant science to inform public policy decisions about air quality and public health. The report highlights the vision underlying HEI’s Strategic Plan 2015-2020 and outlines HEI’s contributions in the past year to important questions.