The Health Effects Institute
"A Partnership of the U.S. Environmental Protection Agency and Industry"

APPENDIX B: HEI Studies and Research Reports (1982–1998)
RFA 82-1: Studies on the metabolism and biological effects of nitropyrene and related nitropolycyclic aromatic compounds
Frederick A. Beland University of Arkansas	The metabolic activation and DNA adducts of dinitropyrenes. (Report No. 4)
James A. Bond Inhalation Toxicology Research Institute	Disposition and metabolism of free and particle-associated nitropyrenes after inhalation. (Report No. 2)
John D. Groopman Boston University School of Public Health	DNA adducts of nitropyrene detected by specific antibodies. (Report No. 7)
Alan M. Jeffrey Columbia University	Metabolic activation of nitropyrenes and diesel particulate extracts. (Report No. 34)
Charles M. King Michigan Cancer Foundation	Metabolism and biological effects of nitropyrene and related compounds. (Report No. 16)
Veronica M. Maher Michigan State University	Studies on the metabolism and biological effects of nitropyrene and related nitro-polycyclic aromatic compounds in diploid human fibroblasts. (Report No. 17)
Richard C. Moon IIT Research Institute	Respiratory carcinogenesis of nitroaromatics. (Report No. 32)
Ronald K. Wolff Inhalation Toxicology Research Institute	Factors affecting possible carcinogenicity of inhaled nitropyrene aerosols. (Report No. 19)
RFA 82-2: Cellular and biochemical markers related to nonneoplastic chronic lung disease
Philip A. Bromberg University of North Carolina at Chapel Hill	Effects of ozone on airway epithelial permeability and ion transport. (Report No. 48)
Edward D. Crandall Cornell University	Effects of nitrogen dioxide on alveolar epithelial barrier properties. (Report No. 13)
Cleamond D. Eskelson University of Arizona	Pulmonary lipotropic factor. (Unpublished report)
John N. Evans University of Vermont	Early markers of lung injury. (Report No. 29)
David A. Johnson East Tennessee State University	Effects of ozone and nitrogen dioxide on human lung proteinase inhibitors. (Report No. 11)
Jawaharlal M. Patel University of Florida	Biochemical and metabolic response to nitrogen dioxide-induced endothelial injury. (Report No. 9)
RFA 82-3: Models of susceptible populations
Marie Amoruso University of Medicine and Dentistry of New Jersey	Estimation of risk of glucose 6-phosphate dehydrogenase deficient red cells to ozone and nitrogen dioxide. (Report No. 1)
Laurence D. Fechter The Johns Hopkins University	Neurotoxicity of prenatal carbon monoxide exposure. (Report No. 12)
Jane Q. Koenig University of Washington	The effects of ozone and nitrogen dioxide on lung function in healthy and asthmatic adolescents. (Report No. 14)
Joe L. Mauderly Inhalation Toxicology Research Institute	Influence of experimental pulmonary emphysema on toxicological effects from inhaled nitrogen dioxide and diesel exhaust. (Report No. 30)
Joe L. Mauderly Inhalation Toxicology Research Institute	Effects of inhaled nitrogen dioxide and diesel exhaust on developing lung. (Report No. 8)
Paul E. Morrow University of Rochester Medical Center	Responses of susceptible subpopulations to nitrogen dioxide. (Report No. 23)
Marc B. Schenker University of California, Davis	Markers of exposure to diesel exhaust in railroad workers. (Report No. 33)
RFA 82-4: Inhalation carcinogenesis studies in rodents: Multifactor interactions
Uwe Heinrich (Ulrich Mohr) Fraunhofer Institut für Toxikologie und Aerosolforschung	Investigation of a potential cotumorigenic effect of the dioxides of nitrogen and sulfur, and of diesel-engine exhaust, on the respiratory tract of Syrian golden hamsters. (Report No. 26)
RFA 82-5: Dose to target tissue
Timothy Crocker University of California, Irvine	Transport of macromolecules and particles at target sites for deposition of air pollutants. (Report No. 3)
RFA 82-7: Health Effects Institute investigatorships
Susan Bagley Michigan Technological University	An investigation into the effect of a ceramic particle trap on the chemical mutagens in diesel exhaust. (Report No. 5)
Deborah M. Drechsler-Parks University of California, Santa Barbara	Effect of nitrogen dioxide, ozone, and peroxyacetyl nitrate on metabolic and pulmonary function. (Report No. 6)
RFA 83-1: Cardiovascular and other health effects of carbon monoxide
Steven M. Horvath University of California, Santa Barbara	Maximal aerobic capacity at several ambient concentrations of carbon monoxide at several altitudes. (Report No. 21)
James J. McGrath Texas Tech University Health Sciences Center	Cardiovascular effects of chronic carbon monoxide and high-altitude exposure. (Report No. 27)
Arthur Penn NYU Medical Center	Determination of the atherogenic potential of inhaled carbon monoxide. (Report No. 57)
Special Request
Multicenter Study of Subjects with Angina: Acute effects of carbon monoxide exposure on individuals with coronary artery disease. (Report No. 25)
Eugene R. Bleecker and Sidney O. Gottlieb The Johns Hopkins University School of Medicine
Thomas E. Dahms and Bernard R. Chaitman St. Louis University Medical Center
Jack D. Hackney and Ronald H. Selvester Los Amigos Research and Education Institute, Inc.
Marcello Pagano Harvard School of Public Health
RFA 83-2: Nitrogen oxides and susceptibility to respiratory infections
George J. Jakab The Johns Hopkins University	Modulation of pulmonary defense mechanisms against viral and bacterial infections by acute exposures of nitrogen dioxide. (Report No. 20)
Thomas J. Kulle University of Maryland	Susceptibility to virus infection with exposure to nitrogen dioxide. (Report No. 15)
Richard Rose New England Deaconess Hospital	Altered susceptibility to viral respiratory infection during short-term exposure to nitrogen dioxide. (Report No. 24)
RFA 83-3: Dose of airborne pollutants to target tissues
Michael T. Kleinman University of California, Irvine	The effects of exercise on dose and dose distribution of inhaled automotive pollutants. (Report No. 45)
Morris B. Snipes Inhalation Toxicology Research Institute	Effect of particle loading of the lung on clearance kinetics and particle microdistribution. (Unpublished report)
Chia P. Yu S.U.N.Y., at Buffalo	Predictive models for deposition of inhaled diesel exhaust particles in humans and laboratory species. (Report No. 10)
RFA 83-4: Epidemiologic investigation of effects of automotive emissions
Michael Jacobsen Institute of Occupational Medicine, Edinburgh	Respiratory infections in coal miners exposed to nitrogen oxides. (Report No. 18)
Jonathan M. Samet University of New Mexico	Nitrogen dioxide and respiratory infection: Pilot investigations. (Report No. 28)
RFA 84-2: Acute effects of carbon monoxide on cardiac rhythm
Bernard R. Chaitman St. Louis University Medical Center	Carbon monoxide exposure to subjects with documented cardiac arrhythmias. (Report No. 52)
Jay P. Farber University of Oklahoma	Carbon monoxide and lethal arrhythmias. (Report No. 36)
David S. Sheps University of North Carolina at Chapel Hill	Effects of 4 percent and 6 percent carboxyhemoglobin on arrhythmia production in patients with coronary artery disease. (Report No. 41)
Richard L. Verrier Harvard School of Public Health	Acute effects of carbon monoxide on cardiac electrical stability. (Report No. 35)
RFA 84-3: Mechanisms of oxidant injury
Bruce A. Freeman University of Alabama at Birmingham	Oxidant injury to the alveolar epithelium: Biochemical and pharmacologic studies. (Report No. 54)
David A. Johnson East Tennessee State University	Oxidant effects on rat and human lung proteinase inhibitors. (Report No. 37)
Jerold A. Last University of California, Davis	Synergistic effects of air pollutants: Ozone plus a respirable aerosol. (Report No. 38)
Gerald L. Mechanic University of North Carolina at Chapel Hill	Biochemistry of lung connective tissue and physiology of emphysema. (Unpublished report)
A. Keith Tanswell University of Western Ontario Medical Center	Detection of paracrine factors in oxidant lung injury. (Report No. 22)
Mark J. Utell University of Rochester Medical Center	Mechanisms of nitrogen dioxide toxicity in humans. (Report No. 43)
RFPA 84-5: New methods for assessing health risks from automotive emissions
Theodore T. Puck Eleanor Roosevelt Institute for Cancer Research	Genetic and biochemical approaches at the cellular level to toxicological assessment of environmental agents. (Unpublished report)
RFA 85-1: Health effects of aldehydes
Roland Grafstrom Karolinska Institutet	Pathological effects of automotive emission related aldehydes in cultured human epithelial cells. (Report not available)
George J. Jakab The Johns Hopkins University	Use of physical chemistry and in vitro exposure to investigate the toxicity of formaldehyde bound to carbonaceous particles in the murine lung. (Report No. 53)
Andres Klein-Szanto Fox Chase Cancer Center	Effects of formaldehyde on xeno-transplanted human respiratory epithelium. (Report No. 51)
George Leikauf University of Cincinnati	Mechanisms of aldehyde-induced bronchial reactivity: Role of airway epithelium. (Report No. 49)
RFPA 85-2: New methods for assessing exposure and health risks from automotive emissions
Roger W. Giese Northeastern University	Methods development toward the measurement of polyaromatic hydrocarbon-DNA adducts by mass spectrometry. (Report No. 61)
RFPA 85-3: Health effects of automotive emissions
Frederick A. Beland University of Arkansas	DNA binding by 1-nitropyrene and dinitropyrenes in vitro and in vivo: Effects of nitroreductase induction. (Report No. 31)
RFA 86-1: Genotoxic, carcinogenic, and cocarcinogenic effects of ozone
Carmia Borek Columbia University	Ozone carcinogenesis and cocarcinogenesis in vitro. (Unpublished report)
Kenneth Donaldson (John M. G. Davis) Institute of Occupational Medicine, Edinburgh	Leukocyte-mediated epithelial injury in ozone-exposed rat lung. (Report No. 44)
David G. Thomassen Inhalation Toxicology Research Institute	The role of ozone in tracheal cell transformation. (Report No. 50)
RFA 86-2: Health effects of diesel emissions
Susan Bagley Michigan Technological University	Characterization of particulate- and vapor-phase organic fraction emissions from a heavy-duty diesel engine equipped with a particle trap and regeneration controls. (Report No. 56)
Frederick Beland University of Arkansas	Role of ring oxidation in the metabolic activation of 1-nitropyrene (Report No. 46)
Karam El-Bayoumy American Health Foundation	Biomonitoring of nitropolynuclear aromatic hydrocarbons via protein and DNA adducts. (Report No. 64)
Alan M. Jeffrey Columbia University	Influence of particle-associated organic compounds on the carcinogenicity of diesel exhaust: Identification of genotoxic components in diesel engine emissions by analysis of DNA damage and evaluation of suitability of assays for analysis of human exposure to these emissions. (Unpublished report)
Veronica Maher Michigan State University	Mutations induced by 1-nitrosopyrene and related compounds during DNA replication in human cells and induction of homologous recombination by these compounds. (Report No. 55)
Joe L. Mauderly Inhalation Toxicology Research Institute	Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats: Neoplastic and nonneoplastic lung lesions. (Report No. 68 Part I)
Kurt Randerath Baylor College of Medicine	Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats: DNA Damage. (Report No. 68 Part II)
RFPA 86-4: Health effects of automotive emissions
Jerry K. Davis University of Alabama at Birmingham	Murine respiratory mycoplasmosis: A model to study effects of oxidants. (Report No. 47)
Extensions
Jane Q. Koenig University of Washington	The effects of combined ozone and nitrogen dioxide in adolescent subjects. (Unpublished report)
Jonathan M. Samet University of New Mexico	Nitrogen dioxide and respiratory illness in children. (Report No. 58 Part I: Health outcomes; Part II: Assessment of exposure to nitrogen dioxide; Part III: Quality assurance in an epidemiologic study; Part IV: Effects of housing and meteorologic factors on indoor nitrogen dioxide concentrations)
Chia P. Yu S.U.N.Y. at Buffalo	Retention modeling of diesel exhaust particles in rats and humans. (Report No. 40)
RFA 87-1: Acute and chronic effects of atmospheric oxidants
Jane Q. Koenig University of Washington	Effects of oxidants, combined with sulfuric or nitric acid, on the pulmonary function of adolescents with asthma. (Report No. 70 Part I)
Donald J. Massaro University of Miami School of Medicine	Tolerance to ozone: Cellular and molecular basis. (Report not available)
Mark J. Utell University of Rochester School of Medicine	Effects of sequential sulfuric acid and ozone exposures on the pulmonary function of healthy subjects and subjects with asthma. (Report No. 70 Part II)
RFA 87-2: Behavioral and neurotoxicological effects of methanol and other components of automotive emissions
Mary R. Cook Midwest Research Institute	Effects of methanol vapor on human neurobehavioral measures. (Report No. 42)
RFPA 87-3: New methods for assessing health risks from automotive emissions
James S. Ultman Pennsylvania State University	Non-invasive determination of respiratory ozone absorption: Development of a fast-responding ozone analyzer. (Report No. 39)
RFPA 87-4: Health effects of automotive emissions
Hanspeter R. Witschi University of California, Davis	Failure of ozone and nitrogen dioxide to enhance lung tumor development in hamsters. (Report No. 60)
Beatrice A. Wittenberg Albert Einstein College of Medicine	Effects of carbon monoxide on the isolated heart muscle cells. (Report No. 62)
OTHER 1987 (Not RFA-derived)
Timothy R. Fennell Chemical Industry Institute of Toxicology	Development of methods for measuring biological markers of formaldehyde exposure. (Report No. 67)
RFA 88-1: Ozone and carbon monoxide: Assessment of population exposure and dose
Jack D. Hackney Los Amigos Research and Education Institute, Inc.	Development of samplers for measuring human exposure to ozone: Active and passive samplers for measuring human exposures to ozone. (Report No. 63)
F. Dennis McCool Memorial Hospital of Rhode Island	Measurements of ventilation in freely ranging subjects. (Report No. 59)
Jonathan M. Samet University of New Mexico	Assessment of heart rate as a predictor of ventilation. (Report No. 59)
Yukio Yanagisawa Harvard School of Public Health	Development of samplers for measuring human exposure to ozone: A passive ozone sampler based on a reaction with iodide. (Report No. 63)
RFPA 88-2: Health effects of automotive emissions
Susan T. Bagley Michigan Technological University	Characterization of fuel and aftertreatment device effects on diesel emissions. (Report No. 76)
Frederick Beland University of Arkansas	DNA adduct formation and T lymphocyte mutation induction in F344 rats implanted with tumorigenic doses of 1,6-dinitropyrene. (Report No. 72)
RFA 89-1: Health effects of methanol exposure: Metabolism and pharmacokinetics; fetal and perinatal neurotoxicity; reproductive toxicity
Thomas Burbacher University of Washington	Primate developmental effects of methanol. (Completed)
Michele Medinsky Chemical Industry Institute of Toxicology	Pharmacokinetics of methanol and formate in female cynomolgus monkeys exposed to methanol vapors. (Report No. 77)
Gary M. Pollack University of North Carolina	Maternal-fetal pharmacokinetics of methanol (Report No. 74)
Bernard Weiss University of Rochester	Developmental neurotoxicity of methanol exposure by inhalation in rats. (Report No. 73)
RFA 89-2: Health effects of chronic ozone inhalation - collaborative National Toxicology Program - Health Effects Institute studies: Pilot studies
Ling-Yi Chang Duke University	Immunocytochemical study of the effects of ozone on connective tissue. (HEI Communications No. 1)
Robert A. Floyd Oklahoma Medical Research Foundation	Ozone-mediated oxidative damage to lung nucleic acids. (HEI Communications No. 1)
William C. Parks Jewish Hospital at Washington University Medical Center	Localization of matrix transcripts by in situ hybridization. (HEI Communications No. 1)
Kent E. Pinkerton University of California, Davis	Ozone, extracellular matrix, and epithelial adaptation. (HEI Communications No. 1)
Derek Uchida National Jewish Center for Immunology and Respiratory Medicine	Assessment of airways responsiveness to inhaled methacholine in aged Fischer 344 rats. (HEI Communications No. 1)
Renaud Vincent Duke University	Quantitative ultra-structural analysis of connective tissue in the lungs. (HEI Communications No. 1)
RFPA 89-3: Motor vehicle emissions: Health effects studies; exposure assessment; methods development
Stephen A. Belinsky Inhalation Toxicology Research Institute	Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats: Identification of target genes involved in carbon black and diesel-induced lung cancer. (Report No. 68 Part III)
Paul Howard Case Western Reserve University	The effects of copollutants on the metabolism and DNA binding of carcinogens. (Report No. 66)
Petros Koutrakis Harvard School of Public Health	Development of samplers for measuring human exposure to ozone: A passive ozone sampler based on a reaction with nitrite. (Report No. 63)
George Leikauf University of Cincinnati Medical Center	Activation of eicosanoid metabolism in human airway epithelial cells by ozonolysis products of membrane fatty acids. (Report No. 71)
Veronica Maher Michigan State University	Mutation spectra from T-cells as a biomarker of human exposure to diesel exhaust. (Unpublished report)
James Ultman Pennsylvania State University	Non-invasive determination of respiratory ozone absorption: The bolus-response method. (Report No. 69)
RFA 90-1 Part A: Health effects of chronic ozone inhalation - collaborative NTP-HEI studies: Respiratory function studies
Jack R. Harkema Inhalation Toxicology Research Institute	Consequences of prolonged inhalation of ozone on F344/N rats: Collaborative studies: Effects on pulmonary function. (Report No. 65 Part V)
John Szarek Marshall University School of Medicine	Consequences of prolonged inhalation of ozone on F344/N rats: Collaborative studies: Mechanical properties, responses to bronchoactive stimuli, and eicosanoid release in isolated large and small airways. (Report No. 65 Part II)
RFA 90-1 Part B: Health effects of chronic ozone inhalation - collaborative NTP-HEI studies: Structural, biochemical, and other alterations
Ling-Yi Chang Duke University Medical School	Consequences of prolonged inhalation of ozone on F344/N rats: Collaborative studies: Morphometric analysis of structural alterations in alveolar regions. (Report No. 65 Part VIII)
Jack Harkema Inhalation Toxicology Research Institute	Consequences of prolonged inhalation of ozone on F344/N rats: Collaborative studies: Effects on the nasal mucociliary apparatus. (Report No. 65 Part VII)
Jerold A. Last California Primate Research Center	Consequences of prolonged inhalation of ozone on F344/N rats: Collaborative studies: Content and cross-linking of lung collagen. (Report No. 65 Part I)
William C. Parks Jewish Hospital at Washington University	Consequences of prolonged inhalation of ozone on F344/N rats: Collaborative studies: Extracellular matrix expression in ozone-exposed lungs. (Report No. 65 Part IV)
Kent E. Pinkerton University of California, Davis	Consequences of prolonged inhalation of ozone on F344/N rats: Collaborative studies: Changes in the tracheobronchial epithelium, pulmonary acinus, and lung antioxidant enzyme activity. (Report No. 65 Part IX)
Bhandaru Radhakrishnamurthy Tulane University	Consequences of prolonged inhalation of ozone on F344/N rats: Collaborative studies: Effects of chronic ozone inhalation on complex carbohydrates of lung connective tissue. (Report No. 65 Part III)
Special Requests for Collaborative NTP-HEI Studies
Paul Mellick Battelle Pacific Northwest Laboratories	HEI/NTP collaborative study on chronic ozone exposure in rats - technical assistance. (Completed)
Paul J. Catalano (Louise Ryan) Harvard School of Public Health and Dana-Farber Cancer Institute	Consequences of prolonged inhalation of ozone on F344/N rats: Collaborative studies: Robust composite scores based on median polish analysis. (Report No. 65 Part X)
Additional reports for collaborative NTP-HEI studies
Consequences of prolonged inhalation of ozone on F344/N rats: Collaborative studies: Background and project design. (Report No. 65 Part VI)
Consequences of prolonged inhalation of ozone on F344/N rats: Collaborative studies: Integrative summary. (Report No. 65 Part XI)
RFA 90-2: Clinical studies of sensitivity to ozone
John R. Balmes University of California, San Francisco	Significance of airway responsiveness and airway injury in ozone sensitivity. (Report No. 78)
Mark W. Frampton University of Rochester Medical Center	Mechanisms of airway inflammation in smokers and nonsmokers with varying responsiveness to ozone. (Report No. 78)
Jack D. Hackney Los Amigos Research and Education Institute, Inc.	Response to ozone in the population: Individual and seasonal factors. (Unpublished report)
RFA 90-3: Ozone interaction with biological macromolecules and molecular dosimetry
William A. Pryor Louisiana State University	Aldehydes as ozone dosimeter molecules. (Completed)
RFA 90-6: Theoretical approaches to the analysis of health effects of complex mixtures
William E. Bechtold Inhalation Toxicology Research Institute	Immunoaffinity chromatography in the analysis of toxic effects of complex mixtures. (HEI Communications No. 4)
John G. Dorsey University of Cincinnati	Stationary-phase programming for liquid chromatography: A new concept for separating complex mixtures. (HEI Communications No. 4)
Chris Gennings Virginia Commonwealth University	Using the parallel coordinate axis system to analyze complex mixtures: Determining biological activity and interactions among components. (HEI Communications No. 4)
David L. Springer Battelle Pacific Northwest Laboratories	Supercritical separation and molecular bioassay technologies applied to complex mixtures. (HEI Communications No. 4)
RFA 91-1: Epidemiologic studies of the health effects of long-term ozone exposure
Patrick L. Kinney New York University	Retrospective characterization of ozone exposure. (Report No. 81)
Dana P. Loomis University of North Carolina	Ozone exposure and daily mortality in Mexico City: A time series analysis. (Report No.75)
William C. Navidi University of Southern California	Statistical methods for epidemiologic studies of the health effects of air pollution. (Completed)
John M. Peters University of Southern California	Acute effects of ambient ozone on asthmatic, wheezy, and healthy children. (Report No. 82)
John D. Spengler Harvard University	Respiratory effects of chronic ozone exposure in children. (Completed)
Ira B. Tager University of California, Berkeley	Feasibility study for chronic ozone respiratory effects. (Report No. 81)
RFA 93-1: Novel approaches to extrapolation of health effects for mobile source toxic air pollutants
William E. Bechtold Inhalation Toxicology Research Institute	S-phenylcysteine in albumin as a benzene biomarker. (Completed)
Ian A. Blair Vanderbilt University	Molecular dosimetry of conjugated dienes and aliphatic aldehydes. (Completed)
David Eastmond University of California, Riverside	Characterization and mechanisms of chromosomal alterations induced by benzene in mice and humans. (Completed)
Rogene Henderson Lovelace Respiratory Research Institute	Study of the potential carcinogenicity of butadiene diepoxide in mice and rats. (Completed)
Assieh A. Melikian American Health Foundation	Quantification of benzene by HPLC-MS method: Assessment of the relationship of degree of benzene exposure to differences in the metabolic activation pathways in humans. (Completed)
Leslie Recio Chemical Industry Institute of Toxicology	Determination of mutagenicity and mutational spectrum in human and rodent cells to assess the role(s) of butadiene monoepoxide and butadiene diepoxide in mediating the in vivo genotoxicity of 1,3-butadiene. (Completed)
Kenneth W. Turteltaub Lawrence Livermore National Laboratory and University of California, San Francisco	Benzene metabolism at doses relevant for human air exposures. (1999)
Vernon E. Walker New York State Department of Health	1,3-Butadiene mutagenicity and tumorigenicity in T-lymphocytes of exposed rodents. (Completed)
RFPA 93-2: Health effects of exposure to motor vehicle emissions
Janet Arey University of California, Riverside	Evaluation of the potential health effects of the atmospheric reaction products of polycyclic aromatic hydrocarbons. (Completed)
Jack R. Harkema Michigan State University	Effects of chronic ozone exposure on the bony tissue of nasal turbinates in the rat: Ozone-induced atrophic rhinitis. (Report No.65 Part XII)
Steven Kleeberger The Johns Hopkins University	Mechanisms of chronic ozone exposure: Role of inflammation. (Completed)
Robert R. Mercer Duke University	Parenchymal atrophy from nitric oxide. (Completed)
Kent E. Pinkerton University of California, Davis	Health effects of chronic ozone inhalation. (Report No. 65 Part XIII)
Richard Schlesinger New York University	Ozone-induced airway hyperresponsiveness. (1998)
Steven Thom University of Pennsylvania	Vascular oxidative stress due to low concentrations of carbon monoxide. (Report No. 80)
James S. Ultman Pennsylvania State University	Improvement of a respiratory ozone analyzer. (Report No. 79)
RFA 94-2: Particulate air pollution and daily mortality: Identification of populations at risk and underlying mechanisms
John C. Bailar III McGill University	Particulate air pollution and daily mortality in Montreal, Québec, 1984–1993. (1999)
Douglas W. Dockery Harvard School of Public Health	Does particulate pollution induce hypoxemia? (Completed)
John J. Godleski Harvard School of Public Health	Mechanisms of morbidity and mortality from exposure to ambient air particles. (Completed)
Terry Gordon New York University Medical Center	Adverse health effects of ambient PM10 in compromised animal models. (1998)
Günter Oberdörster University of Rochester Medical Center	Ultrafine particles as inducers of acute lung injury: Mechanisms and correlation with age and disease. (1998)
H. Erich Wichmann GSF-Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Germany	Particulate air pollution and daily mortality: Identification of populations at risk and underlying mechanisms of effect. (1999)
RFPA 94-3: Health effects of exposure to motor vehicle emissions
Roger Giese Northeastern University	Characterization of environmental, polar PAHs. (1999)
Morton Lippmann New York University Medical Center	Association of PM components with daily mortality and morbidity in urban populations. (1999)
Judith Zelikoff New York University Medical Center	Immunomodulation as a mechanism for PM10-induced effects upon host mortality. (1998)
RFQ: Epidemiologists and statisticians to participate in an evaluation of studies of the acute effects of particulate air pollution
Jonathan M. Samet and Scott L. Zeger The Johns Hopkins University	Particulate air pollution and daily mortality: Replication and validation of selected studies. (Phase I Report of the Particle Epidemiology Evaluation Project) Air pollution, weather, and mortality in Philadelphia 1973–1988. (Phase IB Report of the Particle Epidemiology Evaluation Project)
Jonathan M. Samet and Scott L. Zeger The Johns Hopkins University	National Morbidity and Mortality Air Pollution Study (NMMAPS). (2000)
RFA 95-1: Comparative metabolism and health effects of ethers added to gasoline to increase oxygen content
Janet Benson Lovelace Respiratory Research Institute	The toxicokinetics of methyl-tertiary butyl ether inhaled alone and in combination with gasoline vapor. (1999)
Wolfgang Dekant University of Würzburg, Germany	Comparative biotransformation of methyl tert-butyl ether, ethyl tert-butyl ether, and tert-amyl methyl ether in rats and humans. (1998)
Jun-Yan Hong Rutgers University	Role of human cytochrome P450 2E1 in the metabolism and health effects of gasoline ethers. (1999)
RFPA 95-2: Request for preliminary applications on the health effects of exposure to motor vehicle emissions
James Swenberg University of North Carolina at Chapel Hill	Hemoglobin adducts as biomarkers of butadiene exposure and metabolism. (Completed)
RFQ 95-3: Transitional epidemiology studies for benzene or 1,3-butadiene biomarkers
Richard Albertini University of Vermont	Transitional epidemiology studies for benzene or 1,3-butadiene biomarkers. (1999)
Qingshan Qu NYU Medical Center	The validation of biomarkers in humans exposed to benzene. (1999)
RFA 96-1: Mechanisms of particle toxicity: Fate and bioreactivity of particle-associated compounds
Ann Aust Utah State University	Particle characteristics responsible for effects on human lung epithelial cells. (1999)
Alan Dahl Lovelace Respiratory Research Institute	Epithelial penetration and clearance of particle-borne compounds. (2000)
Stephen Holgate Southampton General Hospital	Inflammatory mechanisms with exposure to air pollution particles. (1999)
Debra Laskin Rutgers University	Role of peroxides and macrophages in fine particulate matter toxicity. (2000)
Kent Pinkerton University of California, Davis	Mechanisms of particle toxicity in the respiratory system. (2001)
RFPA 96-2: Request for preliminary applications on the health effects of exposure to air pollutants from motor vehicle emissions
Harvey Checkoway University of Washington	A case-crossover study of fine particulate air pollution and sudden cardiac arrest. (1999)
Jack Harkema Michigan State University	Effects of Mexico City air on rat nasal epithelium: Morphometric analysis. (1998)
RFQ 97-1: Epidemiologists and statisticians to participate in a reanalysis of cohort studies of long-term mortality and particulate air pollution
Daniel Krewski University of Ottawa	Epidemiology reanalysis project. (2000)
RFA 97-2: Assessing personal exposure to selected aldehydes using chemical and biological techniques
Sally Lee-Jane Liu University of Washington	Characterization of aldehyde exposures in general population. (2001)
Junfeng Zhang Rutgers University	Personal and microenvironmental measurements of human exposures to multiple aldehydes in three distinct urban areas. (2001)
Additional study under negotiation.
RFA 98-1: Characterization of exposure to and health effects of particulate matter
Douglas Dockery Harvard University	Association of particulate air pollution with arrhythmias recorded by implanted cardioverter defibrillators. (2000)
Henry Gong Rancho Los Amigos Medical Center	Controlled laboratory evaluation of acute cardiopulmonary responses to concentrated particulates. (2001)
Christine Nadziejko NYU Medical Center	Particulate matter and cardiovascular mortality. (1999)
Kristen Nikula Lovelace Respiratory Research Institute	Mechanisms of particle size- and composition-related adverse health effects in an aged sensitive population of rats. (2000)
Barbara Turpin Rutgers University	Contributions of outdoor PM sources to indoor concentrations and personal exposures: A three-city study. (2001)
Additional studies under negotiation.
RFA 98-3: Epidemiologic investigations of human populations exposed to diesel engine emissions: Feasibility studies
Studies under negotiation.

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