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The Health Effects Institute
"A Partnership of the U.S. Environmental Protection Agency and Industry"


Annual Conference 2000

Exploring Exposure and Risk Issues

 April 9–11, 2000
Emory Conference Center
Atlanta, GA


Program 
Rates and Information
Atlanta Convention and Visitors Bureau 
Fernbank Museum of Natural History   


Scientific Program

HEI Program Coordinators
        Maria Costantini
        Diane Mundt


Sunday April 9, Morning Minisymposium
(separate registration required)
Location: Emory Amphitheater


Emerging Technologies in Molecular Biology and their Application to Environmental Health Issues
Chair:  Seymour Garte, Environmental and Occupational Health Sciences Institute, and HEI Research Committee
An explosion of new technology associated with the Human Genome Project has led to advances in the fields of genomics (understanding genes and their functions), gene expression, and proteomics (understanding protein products and their functions). This minisymposium will introduce some of these molecular biology advances, including their potential uses and limitations, and discuss how they can further our understanding of the health impact of environmental exposures.

9:00 am   Opening remarks, Seymour Garte

                Emerging Technologies

9.10 am   Use of microarray technology in the pharmaceutical industry, Katherine Call, Aventis/Hoechst Corporation

9:50 am   Application of genomics to toxicology, Cynthia Afshari, National Institute for Environmental and Health Science

                Application of New Technologies to Environmental Health Issues

10:30 am   Toxicology studies, George Leikauf, University of Cincinnati Medical Center

10:50 am   Transitional epidemiology studies, Richard Albertini, University of Vermont Medical School

11:10 am   Epidemiology studies, Paolo Boffetta, International Agency for Research on Cancer

11:30 am   Concluding remarks, Seymour Garte

12:00 pm   Lunch


Sunday April 9, Afternoon Session
Location: Emory Amphitheater
1:00 pm    Welcome, Dan Greenbaum, President, Health Effects Institute

Data Access and Availability
Chair: Donald Kennedy, Editor-in-Chief, Science, Stanford University; and HEI Board of Directors
Leaders from government, science, and industry will discuss why some have sought greater access to scientific data; identify key, sometimes practical questions and concerns regarding data access and sharing; and propose constructive solutions to providing access post Shelby legislation.

1:15 pm    Introduction, Donald Kennedy

1:35 pm    Agency Experience and Guidelines, Wendy Baldwin, National Institutes of Health

2:05 pm    Perspective: Industry, Lucinda Minton Langworthy, Counsel, Hunton and Williams

2:25 pm    Perspective: Investigator, David Savitz, University of North Carolina

2:45 pm    General Discussion

3:15 pm    Break

3:30 pm    Poster Session I . Air Pollutants: Exposure Assessment, Epidemiology, and Toxicology
                
    Location: Ballroom

5:30 pm    Opening Reception

7:00 pm    Dinner and Keynote Address: The European Union's Agenda for  Environmental Protection
               
    James Currie, Director General, DG Environment, European Commission
                 Location: Ballroom


Monday April 10, Morning Session

8:30 am     The HEI Strategic Plan: 2000–2005
Dan Greenbaum, President, HEI; Dan Tosteson, Harvard Medical School, and HEI Review Committee Chair; Bob O'Keefe, Vice President, HEI; and Jane Warren, Director of Science, HEI
HEI has developed a new strategic plan to provide vision for its efforts in the new century. In this session, members of the HEI staff and Committees will describe HEI’s future directions and initiatives.

Approaches to Improving Assessment of Exposure to Air Pollutants
Chairs: Thomas Kensler, Johns Hopkins University and HEI Review Committee; and Robert Sawyer, University of California, Berkeley, and HEI Research Committee
The difficulty of accurately assessing individual exposure has long been recognized to be a limitation of epidemiologic studies. This session will focus on methods for improving our ability to reconstruct or determine personal exposure to air pollutants and for reducing exposure measurement error. The session is divided into three parts. The first part will focus on the studies using biomarkers of dose, the second on methods to improve retrospective assessment of exposure to diesel exhaust, and the third on the exposure measurement error in epidemiologic studies of particulate matter.

                  I. Air Toxics Exposure and Biomarkers

9:15 am      Relationship between personal exosure to benzene and urine levels of metabolites, Qingshan Qu and Beverly Cohen, New York University Medical Center; Assieh Melikian, American Health Foundation

10:05 am    Relationship between routes of exposure and blood levels of MTBE, James Prah, US Environmental Protection Agency, and David Ashley, Centers for Disease Control and Prevention

10:40 am    Break

                   II. Diesel Particulate Emissions and Exposure

11:00 am    Changes in particulate emssions over time in a highway tunnel
                  Alan Gertler, Desert Research Institute

11:25 am    Assessment of the feasibility of estimating current and past exposure to diesel exhaust
                  Thomas Smith, Harvard School of Public Health

11:50 am    Validation of methods for evaluating exposure to diesel exhaust
                  Gurumurthy Ramachandran, University of Minnesota

12:30 pm    Lunch

1:00 pm      Luncheon address
                   Norine Noonan, Assistant Administrator, Office of Research and Development, U.S. Environmental Protection Agency


Monday April 10, Afternoon Session

1:30 pm     Poster Session II.  Particulate Matter (PM): Epidemiology and Toxicology

Approaches to Improving Assessment of Exposure to Air Pollutants (Session continued)
Chair: Edo Pellizzari, Research Triangle Institute and HEI Review Committee

                  III. PM Personal Exposure Versus Ambient Measurements: Addressing the Problem of Measurement Error

3:30 pm    Personal exposure to fine particulate matter in elderly subjects: Relation between personal, indoor and outdoor concentrations, Nicole Janssen, University of Wageningen

4:00 pm    Preliminary results of the Baltimore and Atlanta exposure assessment and health effects studies, Petros Koutrakis, Harvard School of Public Health

4:30 pm    The ARIES study: Preliminary results and issues related to an ongoing study of air pollution and health in Atlanta, Ronald Wyzga, Electric Power Research Institute

5:00 pm     Concluding Remarks, Thomas A. Louis, University of Minnesota

5:30 pm     Adjourn

5:50 pm     Buses leave for Fernbank Museum of Natural History

6:00 pm     Reception and Dinner

8:45 pm     Buses leave for Emory Conference Center Hotel


Tuesday April 11 Morning Session

The State of PM Regulation in the U.S. and Europe -  EPA's PM Criteria Document and WHO PM Guidelines
This session will offer the opportunity to learn more about the status of PM regulation in the U.S. and worldwide.

8:30 am     An Update on the review and implementation of the PM National Air Quality Standards
                John Bachman, U.S. Environmental Protection Agency

9:00 am     WHO Air Quality Guidelines for Europe: Air pollution control in the context of transport and health
                 Dieter Schwela, World Health Organization, Geneva

National Mortality and Morbidity Air Pollution Study (NMMAPS)
Chair: Gerald van Belle, University of Washington and HEI Research Committee
NMMAPS is a nationwide epidemiologic study of air pollution and daily morbidity and mortality in 90 U.S. cities. The NMMAPS investigators have also developed methods to estimate reduced in life expectancy associated with short-term exposure to air pollution and to quantify the impact of errors in air pollution exposure measurements on the estimated association of air pollution with daily mortality. In this session, investigators, members of the NMMAPS Oversight Committee, and members of the HEI Review Committee will present and discuss the complete results of the analyses.

9:30 am       Introduction, Gerald van Belle

9:40 am       Presentation of results on morbidity and mortality, Jonathan Samet, Scott Zeger, and Francesca Dominici, Johns Hopkins University; Douglas Dockery and Joel Schwartz, Harvard School of Public Health

10:20 am     Break

10:40 am   Presentation of Results on Morbidity and Mortality (continued)

11:00 am   Comments from the HEI NMMAPS Review Panel and perspective on the future of epidemiological research on acute effects of air pollution, Sverre Vedal, University of British Columbia, NMMAPS Review Panel, and HEI Review Committee

11:20 am   General Discussion

12:00 pm    Lunch


Tuesday April 11 Afternoon Session

The HEI Epidemiology Reanalysis Project
Chair: Arthur Upton, Environmental & Occupational Health Sciences Institute and Chair of the HEI Epidemiology Reanalysis Project Expert Panel
The Epidemiology Reanalysis Project is an independent reanalysis of the Harvard Six-Cities and American Cancer Society studies of fine particulate air pollution and mortality. The project objectives are: 1) to validate the published results of the two studies by conducting quality assurance on samples of the original data sets and attempting to reproduce the original results and 2) to conduct sensitivity analyses to test the robustness of the original findings and the interpretation to alternative analytic approaches. In this session, investigators and members of the HEI Expert Panel overseeing the project study will present results of both the validation and the sensitivity analyses.

1:00 pm     Key scientific issues in the Reanalysis of the Harvard Six Cities and American Cancer Society studies
                 Clarice Weinberg, National Institute of Environmental Health Sciences and HEI Epidemiology Reanalysis Project Expert Panel

1:20 pm     Preliminary Results, Daniel Krewski and Rick Burnett, University of Ottawa 

2:10 pm     Comments from the Review Panel, Millicent Higgins, University of Michigan and Chair, HEI Epidemiology Reanalysis Review Panel

2:30 pm     General Discussion

3:25 pm     Closing Remarks, Dan Greenbaum

3:30 pm     Conference Adjourns


Meeting Rates*  (hotel not included)

Full Conference ......................................................................................................$440
Sunday afternoon through Tuesday (includes all meals, Sunday lunch through Tuesday lunch)

Single Day Rates

  • Sunday Includes lunch, break, reception and dinner........... ...$140
  • Monday Includes three meals, breaks and reception..............$180
  • Tuesday Includes breakfast, break and lunch........................$120
  • Day Rates including breaks and lunch only.............................$80

*Please contact HEI for U.S. Government rates

For registration form and further information:

Gail Allosso
Health Effects Institute
955 Massachusetts Avenue
Cambridge, MA 02139, USA
telephone: +1-617-876-6700
fax: +1-617-876-6709
E-mail: gallosso@healtheffects.org


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